Commentary
SvO2 to monitor resuscitation of septic patients: let's just understand the basic physiology
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* Corresponding author: Jean-Louis Teboul jean-louis.teboul@bct.aphp.fr
1 Service de Réanimation Médicale, Hôpital de Bicêtre, Hôpitaux Universitaires Paris-Sud, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France
2 Faculté de Médecine Paris-Sud, Université Paris-Sud, EA 4046, 63 rue Gabriel Péri, 94270 Le Kremlin-Bicêtre, France
3 Service de Réanimation Médicale, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris-Sud, 157 rue de la Porte des Trivaux, 92141 Clamart, France
Critical Care 2011, 15:1005 doi:10.1186/cc10491
Published: 7 November 2011Abstract
Real-time monitoring of mixed venous oxygen blood saturation (SvO2) or of central venous oxygen blood saturation is often used during resuscitation of septic shock. However, the meaning of these parameters is far from straightforward. In the present commentary, we emphasize that SvO2 - a global marker of tissue oxygen balance - can never be simplistically used as a marker of preload responsiveness, which is an intrinsic marker of cardiac performance. In some septic shock patients, because of profound hypovolemia or myocardial dysfunction, SvO2 can be low but obviously cannot alone indicate whether a fluid challenge would increase cardiac output. In other patients, because of a profound impairment of oxygen extraction capacities, SvO2 can be abnormally high even in patients who are still able to respond positively to fluid infusion. In any case, other reliable dynamic parameters can help to address the important question of fluid responsiveness/unresponsiveness. However, whether fluid administration in fluid responders and high SvO2 would be efficacious to reduce tissue dysoxia in the most injured tissues is still uncertain.