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Highly Accessed Commentary

How to approach genome wars in sepsis?

Jack Hawiger1* and James M Musser2

Author Affiliations

1 Vanderbilt University School of Medicine, Department of Medicine, Division of Allergy Pulmonary and Critical Care Medicine, 1161 21st Avenue South, T-1218 MCN, Nashville, TN 37232-2650, USA

2 Department of Pathology and Genomic Medicine, The Methodist Hospital System and Research Institute, 6565 Fannin Street, B490, Houston, Texas 77030, USA

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Critical Care 2011, 15:1007  doi:10.1186/cc10482

Published: 2 December 2011

Abstract

Sepsis continues to pose a clear challenge as one of the most difficult and costly problems to treat and prevent. Sepsis is caused by systemic or localized infections that damage the integrity of microcirculation in multiple organs. The challenge of sepsis and its long-term sequelae was addressed by the National Institutes of Health National Heart Lung and Blood Institute Division of Blood Diseases and Resources. Defining sepsis as severe endothelial dysfunction syndrome that causes multiorgan failure in response to intravascular or extravascular microbial agents, the National Heart Lung and Blood Institute panel proposed the concept of genome wars as a platform for new diagnostic, therapeutic, and preventive approaches to sepsis.