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Commentary

Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers

Michael J Hobson and Hector R Wong*

Author Affiliations

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA

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Critical Care 2011, 15:1009 doi:10.1186/cc10527


See related research by Turrrel-Davin et al., http://ccforum.com/content/15/5/R252

Published: 7 December 2011

Abstract

Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which patients may be appropriately stratified in such clinical trials.