Table 2

Demography, injury severity, transfusions, mortality, hemostasis and biomarkers of coagulopathy in ACoTS and non-ACoTS patients

ACoTS

Normal

(no ACoTS)

p to value


Demography

N

12

68

Age

yrs

42 (26 to 74)

46 (34 to 63)

NS

Gender

m% (n)

75% (9)

66% (45)

NS

Blunt trauma

% (n)

92% (11)

91% (62)

NS

ISS

score

34 (30 to 43)

17 (10 to 25)

< 0.001

sTBI

% (n)

25% (3)

32% (19)

NS

GCS (PH)

score

3 (3 to 7)

13 (7 to 15)

< 0.001

Shockindex (PH)

HR/SBP

0.68 (0.56 to 0.78)

0.61 (0.48 to 0.75)

NS

RBC 1 h

n

5 (0 to 9)

0 (0 to 0)

< 0.001

MT (> 10 RBC in 24 h)

% (n)

50% (6)

7% (5)

< 0.001

Mortality

% (n)

50% (6)

12% (8)

0.001

Shock, biochemistry and coagulopathy

pH

7.27 (7.13 to 7.31)

7.36 (7.31 to 7.40)

0.001

SBE

mmol/l

-5.1 (-8.2 to -2.35)

-1.8 (-3.4 to 0.0)

0.009

Hemoglobin

mmol/l

6.8 (5.8 to 8.8)

8.5 (7.6 to 9.0)

0.055

Platelet count

109/l

197 (173 to 238)

208 (176 to 259)

NS

Fibrinogen

g/l

1.53 (1.25 to 2.02)

2.45 (2.18 to 2.89)

0.001

FXIII

microg/ml

23 (17 to 29)

30 (24 to 39)

0.004

vWF

%

143 (100 to 209)

201 (140 to 226)

0.117

APTT

sec

33 (27 to 42)

25 (23 to 26)

NA

INR

ratio

1.3 (1.3 to 1.5)

1.1 (1.1 to 1.1)

NA

Tissue, endothelial cell and glycocalyx injury

Histone-complexed DNA

%

15.4 (8.5 to 58.2)

4.8 (0.1 to 11.8)

0.003

Annexin V

ng/ml

45 (40 to 61)

24 (21 to 35)

0.001

sTM

ng/ml

2.90 (2.27 to 4.09)

1.43 (0.92 to 3.34)

0.015

Syndecan-1

ng/ml

62 (34 to 107)

31 (18 to 48)

0.013

Thrombin generation

PF1.2

nmol/l

3.17 (0.61 to 16.03)

6.71 (2.08 to 18.79)

0.120

TAT

ng/ml

38 (36 to 41)

36 (30 to 43)

NS

Natural anticoagulation

AT

103 U/l

0.68 (0.62 to 0.85)

0.95 (0.87 to 1.03)

< 0.001

PC

%

72 (60 to 89)

114 (99 to 129)

< 0.001

APC

ng/ml

9.98 (8.59 to 11.96)

9.78 (7.72 to 12.15)

NS

sEPCR

ng/ml

174 (141 to 242)

230 (175 to 398)

0.087

PS

%

57 (50 to 69)

66 (61 to 71)

0.078

TFPI

ng/ml

63 (43 to 74)

60 (47 to 80)

NS

Fibrinolysis

D-dimer

ng/ml

174 (173 to 176)

158 (122 to 173)

0.001

tPA

ng/ml

7.2 (5.5 to 11.8)

6.9 (3.5 to 12.6)

NS

PAI

ng/ml

26 (11 to 37)

22 (14 to 40)

NS

Inflamamtion

sC5b-9

ng/ml

1, 014 (701 to 1, 173)

1, 027 (905 to 1, 232)

NS

IL-6

pg/ml

110 (98 to 128)

61 (18 to 118)

0.024


Data are presented as medians (IQR) or n (%), with P-values shown for variables with P < 0.200, and in bold for P < 0.050. Patients with or without ACoTS were compared by Wilcoxon Rank Sum tests or Chi-square/Fischer exact tests, as appropriate.

APTT, activated partial thromboplastin time; GCS, Glascow Coma Score scale; INR, international normalized ratio; ISS, injury severity score; MT, > 10 RBC the initial 24 hours; RBC, red blood cells; sTBI, severe Traumatic Brain Injury, Abbreviated Injury Score head > 3; PH, pre-hospital at the site of injury.

Biomarker abbreviations, see Materials and methods section, ELISA and the List of abbreviations.

Johansson et al. Critical Care 2011 15:R272   doi:10.1186/cc10553

Open Data