Table 1

Differences between HYPOLYTE and CRASH studies

CRASH STUDY

HYPOLYTE STUDY

Number of patients

10,000

150

Primary end point

Mortality

Pneumonia incidence

Time to administration of first dose of steroid

< 8 hours

Within 36 hours of trauma; 25 hours (median)

Steroid loading dose

2 gms

None

Duration of Steroids

48 hours

1 week

Aleti and Yende Critical Care 2011 16:301   doi:10.1186/cc10596