Table 5

Proposed diagnostic criteria of kidney dysfunction in cirrhosis [47]

Diagnosis

Definition


Acute Kidney Injury

• A rise in Scr ≥ 50% from baseline, or a rise Scr > 0.3 mg/dL

• Type-1 HRS is a specific form of acute kidney injury

Chronic Kidney Disease

• GFR < 60 ml/min for > 3 month calculated using MDRD-6 formula

Acute on Chronic Kidney Disease

• Rise in Scr ≥ 50% from baseline or a rise of Scr > 0.3 mg/dL in a patient with cirrhosis whose GFR is < 60 ml/min for > 3 month calculated using MDRD-6 formula


GFR, glomerular filtration rate; HRS, hepatorenal syndrome; Scr, serum creatinine. Both the acute deterioration in renal function and the background chronic renal dysfunction can be functional or structural in nature. MDRD-6: GFR = 170 × Scr (mg/dL)-0.999 x age-0.176 x 1.180 (if black) × 0.762 (if female) × serum urea nitrogen-0.170 × albumin0.138

Nadim et al. Critical Care 2012 16:R23   doi:10.1186/cc11188

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