Table 4 |
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|
Baseline characteristics, therapy, and outcomes between early (≤ 6 hour) and late (> 6 hour) low-dose corticosteroid therapy groups |
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|
Variables |
Early group, ≤ 6 hour (number = 66) |
Late group, > 6 hour (number = 112) |
P-value |
|
|
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|
Age, years |
67 (55-71) |
65 (53-71) |
0.8142 |
|
Sex, male |
42 (64) |
65 (58) |
0.4611 |
|
Severity of illness |
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|
SAPS 3 |
80 (71-89) |
82 (72-91) |
0.146 |
|
SOFA |
11 (9-13) |
11 (9-14) |
0.6498 |
|
Site of infection |
0.7997 |
||
|
Lung |
27 (41) |
53 (47) |
|
|
Gastrointestinal tract |
20 (30) |
27 (24) |
|
|
Urinary tract |
9 (14) |
10 (9) |
|
|
Catheter related |
3 (4) |
2 (2) |
|
|
Skin and soft tissue |
1 (2) |
5 (4) |
|
|
Others |
6 (9) |
15 (14) |
|
|
Bacteremia |
28 (42) |
39 (35) |
0.3119 |
|
Time to initiation of antibiotic therapy, hour |
0.1 (-3.3-1.2) |
0.1 (-4.9-1.9) |
0.9659 |
|
Appropriate antibioticsa |
36/42 (86) |
46/62 (74) |
0.1581 |
|
Laboratory data |
|||
|
Leukocytes, 103/mm3 |
6.9 (0.3-16.5) |
10.2 (0.1-18.1) |
0.1797 |
|
Platelet, 103/mm3 |
75 (35-148) |
68 (40-155) |
0.5662 |
|
Total bilirubin, mg/dL |
1.4 (0.9-2.7) |
1.4 (0.9-1.7) |
0.9519 |
|
Creatinine, mg/dL |
1.7 (1.0-2.5) |
1.4 (0.9-2.4) |
0.1673 |
|
Prothrombin time, s |
61 (47-68) |
54 (42-66) |
0.2931 |
|
Albumin, g/dL |
3.0 (2.3-3.3) |
2.6 (2.4-3.1) |
0.0811 |
|
Initial lactate, mmol/L |
4.1 (2.8-5.7) |
3.8 (2.6-6.6) |
0.8798 |
|
Organ failureb |
|||
|
Respiratory |
48 (73) |
90 (80) |
0.2388 |
|
Coagulation |
43 (65) |
66 (59) |
0.4105 |
|
Liver |
24 (36) |
40 (36) |
0.9305 |
|
Renal |
28 (42) |
39 (35) |
0.3119 |
|
Amount of fluid administered before vasopressor, L |
1.6 (1.0-2.3) |
1.5 (1.1-2.2) |
0.1932 |
|
Vasopressor (norepinephrine or equivalent) dose, μg/kg/min |
0.50 (0.32-1.06) |
0.52 (0.29-0.80) |
0.6277 |
|
Need for mechanical ventilation |
38 (58) |
86 (77) |
0.0071 |
|
Need for renal replacement therapy |
19 (29) |
39 (35) |
0.4068 |
|
CIRCIc |
16/23 (70) |
62/73 (85) |
0.1269 |
|
Relative adrenal insufficiencyc |
15/23 (65) |
56/73 (77) |
0.2733 |
|
Outcomes |
|||
|
Reversal of shock |
50 (76) |
70 (63) |
0.0683 |
|
ICU mortality |
21 (32) |
55 (49) |
0.0243 |
|
Length of stay in ICU, days |
4 (3-8) |
7 (4-12) |
0.004 |
|
28-day mortality |
21 (32) |
57 (51) |
0.0132 |
|
90-day mortality |
27 (41) |
72 (64) |
0.0024 |
|
In-hospital mortality |
29 (44) |
75 (67) |
0.0026 |
|
Length of stay in hospital, days |
16 (7-28) |
18 (7-30) |
0.6974 |
|
|
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|
CIRCI, critical-illness-related corticosteroid insufficiency; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment. aAppropriate antibiotics were based on the site of infection and available cultures. bOrgan failure was defined as SOFA score of ≥ 2 or more per system. cThe results of adrenocorticotropic hormone test were available for 96 (54%) patients. |
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|
Park et al. Critical Care 2012 16:R3 doi:10.1186/cc10601 |
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