Administration of pharmacological antipyretic treatments (NSAIDs and/or acetaminophen) in each MAXICU category. Data show patients categorized in subgroups according to MAXICU value range: 37.5°C to 38.4°C, 38.5°C to 39.4°C and ≥ 39.5°C. White bar, patients given NSAIDs; black bar, patients given acetaminophen; gray bar, patients given both NSAIDs and acetaminophen. For the subgroup with MAXICU of 37.5°C to 38.4°C, the proportion of patients received pharmacological antipyretic treatments was significantly higher in non-septic patients (P = 0.007). For the rest of the subgroups, it was not significantly different between patients with and without sepsis (38.5°C to 39.4°C, P = 0.62; ≥ 39.5°C, P = 0.25). Acetaminophen was used more frequently for patients with sepsis, and NSAIDs for patients without sepsis in each MAXCAT subgroup (P < 0.001). MAXICU, maximum body temperature recorded during ICU stay; NSAIDs: non-steroid anti-inflammatory drugs.
Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group et al. Critical Care 2012 16:R33 doi:10.1186/cc11211