Table 1 |
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|
Comparison of baseline characteristics of patients with and without sepsis |
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|
Patients with sepsis (N = 606) |
Patients without sepsis (N = 819) |
P-value |
Total cohort (N = 1425) |
|
|
|
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|
28-day mortality n (%) |
135 (22.3%) |
36 (4.4%) |
< 0.001 |
171 (12.0%) |
|
Gender (male) n (%) |
385 (63.5%) |
508 (62%) |
0.56 |
893 (62.7%) |
|
Age (y.o, IQR) |
67 (55, 75) |
65 (54, 73) |
0.015 |
66 (54, 74) |
|
APACHE II score (IQR) |
21 (16, 25) |
14 (10, 18) |
< 0.001 |
17 (12, 22) |
|
Mechanical ventilation requirement n (%) |
429 (70.8%) |
528 (64.5%) |
0.01 |
957 (67.2%) |
|
Postoperative admission n (%) |
68 (11.2%) |
538 (65.7%) |
< 0.001 |
602 (42.2%) |
|
Reasons for admission n (%) |
||||
|
Cardiac or vascular disease |
109 (18.0%) |
435 (53.1%) |
< 0.001 |
544 (38.2%) |
|
Thoracic or respiratory disease |
343 (56.6%) |
205 (25.0%) |
< 0.001 |
548 (38.4%) |
|
Renal or metabolic disease |
61 (10.0%) |
54 (6.6%) |
0.018 |
115 (8.1%) |
|
Gastrointestinal tract disease |
68 (11.2%) |
108 (13.1%) |
0.26 |
176 (12.4%) |
|
Other |
25 (4.1%) |
17 (2.1%) |
0.024 |
42 (2.9%) |
|
Length of stay in ICU |
8 (5, 14) |
5 (4, 7) |
< 0.001 |
6 (4, 10) |
|
MAXICU (°C, IQR) |
38.3 (37.7, 39.0) |
37.8 (37.4, 38.3) |
< 0.001 |
38.0 (37.5, 38.6) |
|
< 36.5°C |
4 (0.7%) |
2 (0.2%) |
0.43 |
6 (0.4%) |
|
36.5°C to 37.4°C |
98 (16.2%) |
240 (29.3%) |
< 0.001 |
338 (23.7%) |
|
37.5°C to 38.4°C |
237 (39.1%) |
425 (52.0%) |
< 0.001 |
662 (46.5%) |
|
38.5°C to 39.4°C |
185 (30.5%) |
125 (15.3%) |
< 0.001 |
310 (21.8%) |
|
≥ 39.5°C |
82 (13.5%) |
27 (3.3%) |
< 0.001 |
109 (7.6%) |
|
NSAIDs |
||||
|
Number of patients administered n (%) |
31 (5.1%) |
99 (12.1%) |
< 0.001 |
130 (9.1%) |
|
Delta body temperature* (°C, IQR) |
-0.3 (-0.8, 0.0) |
-0.4 (-0.7, 0.0) |
0.57 |
-0.3 (-0.7, 0.0) |
|
Acetaminophen |
||||
|
Number of patients administered n (%) |
116 (19.1%) |
32 (3.9%) |
< 0.001 |
148 (10.4%) |
|
Delta body temperature* (°C, IQR) |
-0.4 (-0.8, -0.2) |
-0.3 (-0.7, 0.0) |
0.14 |
-0.4 (-0.9, -0.2) |
|
Physical cooling |
||||
|
Number of patients administered n (%) |
307 (50.7%) |
364 (44.4%) |
0.02 |
671 (47.1%) |
|
Delta body temperature* (°C, IQR) |
-0.2 (-0.5, 0.0) |
-0.1 (-0.3, 0.0) |
< 0.001 |
-0.1 (-0.3, 0.0) |
|
|
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|
APACHE, Acute Physiology and Chronic Health Evaluation; IQR, 25%, 75% interquartile; MAXICU, maximum body temperature during ICU stay; NSAIDs, non-steroid anti-inflammatory drugs *, Delta body temperature from application of antipyretic to next temperature monitoring |
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|
Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group et al. Critical Care 2012 16:R33 doi:10.1186/cc11211 |
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