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Highly Accessed Review

Repair after acute lung injury: molecular mechanisms and therapeutic opportunities

Adrián González-López and Guillermo M Albaiceta*

Author Affiliations

Department of Functional Biology, Physiology Area, Faculty of Medicine, University of Oviedo, Julian Claveria s/n, 33006 Oviedo, Spain

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Critical Care 2012, 16:209  doi:10.1186/cc11224

Published: 20 March 2012

First paragraph (this article has no abstract)

Acute lung injury (ALI) is a clinical syndrome characterized by impairment in gas exchange and/or lung mechanics that leads to hypoxemia and increased work of breathing (WOB). When respiratory failure occurs, most patients require mechanical ventilation. This clinical scenario is related to high morbidity and mortality rates.