Carboxyhemoglobin levels during human inflammation
1 Department of Intensive Care, Radboud University Nijmegen Medical Centre, Geert Grooteplein-zuid 10, 6525 GA Nijmegen, The Netherlands
2 Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands
3 Nijmegen Intitute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Geert Grooteplein-zuid 10, 6525 GA Nijmegen, The Netherlands
Critical Care 2012, 16:24 doi:10.1186/cc11295
See related research by Fazekas et al., http://ccforum.com/content/16/1/R6Published: 23 April 2012
First paragraph (this article has no abstract)
In agreement with the study by Fazekas and colleagues  in a recent issue of Critical Care, an increase in the concentration of carbon monoxide (CO) has been observed after surgery and cardiopulmonary bypass and during sepsis . Although inflammation induces heme oxygenase and the above-mentioned conditions do lead to inflammation, a clear association in humans has not been established, underlining the relevance of the remarks made by Cove and Pinsky  in the same issue of Critical Care. We would like to present data that illustrate that inflammation does increase CO in humans in vivo.