Table 1 |
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Baseline data for eligible patients. |
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|
Cohort, n = 1215 |
Progressed to AOF, n = 45 (37.2%) |
No progression to AOF, n = 76 (62.8%) |
P-value |
|
|
|
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Demographic data1 |
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|
Age |
56.0 (19.1) |
58.1 (19.8) |
54.7 (18.7) |
0.432 |
|
Female gender |
40 (33.1) |
15 (33.3) |
25 (32.9) |
1.0 |
|
APACHE II |
13.8 (6.3), n = 120 |
15.8 (5.6) |
12.5 (6.2), n = 75 |
0.005 |
|
Chronic comorbidities |
53 (43.8) |
22 (49.0) |
31 (40.8) |
0.45 |
|
Current smoker |
23 (19.0), n = 83 |
12 (26.7), n = 34 |
11 (14.5), n = 36 |
0.19 |
|
Previous statin therapy |
26 (21.5), n = 105 |
8 (17.8), n = 36 |
18 (23.7), n = 69 |
0.23 |
|
|
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|
Admission characteristics2 |
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|
Reason for admission: |
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|
Respiratory infection |
21 (17.4) |
10 (22.2) |
11 (14.5) |
0.277 |
|
COPD/Asthma |
8 (6.6) |
2 (4.4) |
6 (7.9) |
0.709 |
|
Respiratory |
31 (25.6) |
8 (17.8) |
23 (30.3) |
0.128 |
|
Sepsis & septic shock |
7 (5.8) |
5 (11.1) |
2 (2.6) |
0.100 |
|
Shock (CVS) |
8 (6.6) |
5 (11.1) |
3 (4.0) |
0.146 |
|
CVS (other) |
4 (3.3) |
2 (4.4) |
2 (2.6) |
0.628 |
|
Trauma |
17 (14.1) |
7 (15.6) |
10 (13.2) |
0.714 |
|
Neurological |
4 (3.3) |
0 (0.0) |
4 (5.3) |
0.296 |
|
Drug overdose |
2 (1.7) |
0 (0.0) |
2 (2.6) |
0.529 |
|
Gastrointestinal |
18 (14.9) |
6 (13.3) |
12 (15.8) |
0.714 |
|
Other |
1 (0.8) |
0 (0.0) |
1 (1.3) |
1.000 |
|
Admission source |
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|
OPR/Theatre |
43 (35.5) |
11 (24.4) |
32 (42.1) |
0.050 |
|
Hospital floor/ward |
30 (24.8) |
15 (33.3) |
15 (19.7) |
0.094 |
|
ER/A&E |
30 (24.8) |
10 (22.2) |
20 (26.3) |
0.614 |
|
Other hospital area |
5 (4.1) |
2 (4.4) |
3 (4.0) |
1.000 |
|
Another hospital |
13 (10.7) |
7 (15.6) |
6 (7.9) |
0.188 |
|
Other: |
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|
Readmission to ICU |
12 (9.9) |
4 (8.9) |
8 (10.5) |
1.0 |
|
Admitted with any infection |
28 (23.1) |
15 (33.3) |
13 (17.1) |
0.041 |
|
Admitted with pneumonia3 |
21 (75.0) |
12 (80.0) |
9 (69.2) |
0.67 |
|
Positive microbiological cultures3 |
42 (40.4) |
17 (43.6) |
25 (38.5) |
0.606 |
|
|
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|
Organ function - SOFA score4 |
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|
Respiratory |
2 (3) |
3(3) |
2(3) |
0.019 |
|
Renal |
0 (1) |
0(1) |
0(0) |
0.048 |
|
Haematological |
0(0) |
0(1) |
0(0) |
0.197 |
|
Cardiovascular |
1(1) |
1(3) |
1(1) |
0.002 |
|
Hepatic |
0(0) |
0(1) |
0(0) |
0.016 |
|
Neurological |
2(4) |
3(3) |
2(3) |
0.016 |
|
Total SOFA score |
4(4) |
5(5) |
3(3) |
< 0.0001 |
|
Total SOFA score excluding respiratory |
1(2) |
3(4) |
1(2) |
< 0.0001 |
|
|
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|
1Mean (SD) or total (%) unless otherwise indicated. 2N, (%). 3Further data available in the online addendum. 4Presented as median and interquartile range. 5Two patients were discharged soon after admission. AOF, acute organ failure; APACHE, acute physiology and chronic health evaluation; COPD, chronic obstructive pulmonary disease; CVS, cardiovascular; ER/A&E, emergency room/accident & emergency; ICU, intensive care unit; OPR, operating room; SOFA, sequential organ failure assessment. |
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|
Terblanche et al. Critical Care 2012 16:R61 doi:10.1186/cc11306 |
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