Table 3

Risk factors associated with acute organ failure.

Predictor variable

Univariate analysis

Multivariate analysis (n = 108)

OR¹

95% CI

P-value

OR¹

95% CI¹

P-value^{2, 3}

Age (years)

1.00

0.99 - 1.03

0.339

0.381

APACHE II

1.09

1.02 - 1.17 (n = 120)

0.008

1.08

1.00 - 1.17

0.064

Female gender

1.02

0.47 - 2.23

0.960

0.668

OPR/Theatre admission

0.44

0.20 - 1.01

0.052

0.324

Admission PaO2/FiO2 ratio

0.80

0.58 - 1.00 (n = 114)

0.038

0.498

Hypoxemic failure

4.56

1.98 - 10.53

(n = 120)

< 0.001

5.63

1.95 - 16.26

0.001

Type 2 (ventilatory) failure

0.11

0.01 - 0.86 (n= 120)

0.035

0.208

Positive end-expiratory pressure support (PEEP) only

0.14

0.02 - 1.12 (n = 116)

0.064

0.411

PEEP and positive pressure inspiratory support

8.95

1.12 - 71.42 (n = 116)

0.039

7.00

0.61 - 79.79

0.117

Endotracheal tube

2.76

1.16 - 6.59 (n = 116)

0.022

0.353

Previous statin therapy

1.10

0.98 - 1.24

0.112

1.16

0.99 - 1.35

0.064

Statin on ICU day 1

0.35

0.09 - 1.32 (n = 116)

0.122

0.18

0.03- 1.13

0.068

Admitted with an infection

2.42

1.02 - 5.73

0.044

0.985

Admission lactate

1.06

0.86 - 1.32 (n = 110)

0.579

0.209

Admission white cell count

1.00

0.93 - 1.06 (n = 115)

0.880

0.570

Cardiovascular dysfunction

2.80

1.55 - 5.05

0.001

2.06

1.02 - 4.14

0.044

Renal dysfunction

2.21

1.10 - 4.45

0.026

2.32

0.93 - 5.79

0.070

Hepatic dysfunction

2.67

1.11 - 6.39

0.028

0.248

Haematological dysfunction

1.86

0.87 - 3.99

0.111

0.714

¹OR (odds ratio) per one unit change, as appropriate for each variable. ²Value adjusted for other variables when OR and 95% CI (confidence interval) presented. ³Likelihood ratio value for variable selection when OR and 95% CI not presented. APACHE, acute physiology and chronic health evaluation; ICU, intensive care unit; OPR, operating room; PaO2/FiO2,

Terblanche et al. Critical Care 2012 16:R61   doi:10.1186/cc11306