Highly Accessed Letter

ROTEM®-guided coagulation factor concentrate therapy in trauma: 2-year experience in Venice, Italy

Alberto Grassetto*, Marco De Nardin, Bernadetta Ganzerla, Monica Geremia, Debora Saggioro, Elena Serafini, Silvia Zampieri, Manuela Toffoli, Daniele Penzo, Antonio Bossi and Carlo Maggiolo

Author Affiliations

Dipartimento Emergenza Urgenza, UOC Anestesia e Rianimazione, Ospedale dell'Angelo di Mestre, Via Paccagnella 11, 30174 Zelarino, Venice, Italy

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Critical Care 2012, 16:428 doi:10.1186/cc11322

Published: 21 May 2012

First paragraph (this article has no abstract)

Haemostatic therapy for trauma-induced coagulopathy is typically based on administration of allogeneic blood products, although the evidence supporting this approach is poor [1]. Fixed-ratio protocols have been proposed for administering fresh frozen plasma, red blood cells and platelets, but the optimal ratio has not been established and the speed of intervention may be more important [2].