Table 2 |
||
|
Patient demographic and baseline characteristics. |
||
|
HES 130/0.4 (n = 100) |
NaCl 0.9% (n = 96) |
|
|
|
||
|
Gender, n (%) |
||
|
- Male |
64 (64) |
57 59) |
|
- Female |
36 (36) |
39 (41) |
|
Age, years, mean ± SD |
65.8 ± 15.4 |
65.9 ± 14.7 |
|
Race, n (%) |
||
|
- Caucasian |
96 (96) |
93 97) |
|
- Asian |
1 (1) |
1 (1) |
|
- Black |
1 (1) |
1 (1) |
|
- Other |
2 (2) |
1 (1) |
|
Mean body mass index, kg/m2 |
26.2 |
26.0 |
|
Type of patient, n (%) |
||
|
- Medical |
73 (73) |
70 73) |
|
- Surgical |
27 (27) |
26 (27) |
|
Renal impairment prior to screening*, n (%) |
62 (63.9) |
65 (68.4) |
|
SAPS II prior to randomization, mean |
50 |
53 |
|
SOFA at screening, mean |
7.9 |
9.1 |
|
Fluid input prior to randomization, ml/kg body weight, mean ± SD |
35.5 ± 25.3 |
39.9 ± 28.6 |
|
Origin of sepsis, n (%) |
||
|
- Lungs |
53 (53) |
58 (60) |
|
- Abdomen |
24 (24) |
18 (19) |
|
- Urogenital |
8 (8) |
14 (15) |
|
- Skin, bone and soft tissue |
6 (6) |
4 (4) |
|
- Other |
5 (5) |
2 (2) |
|
- Unknown |
4 (4) |
2 (2) |
|
- Neurological system |
3 (3) |
2 (2) |
|
- Ear nose and throat |
2 (2) |
0 (0) |
|
Causative organism, n (%) |
||
|
- Gram-negative bacteria |
35 (35) |
41 (43) |
|
- Gram-positive bacteria |
25 (25) |
27 (28) |
|
- Other classes |
40 (40) |
32 (33) |
|
|
||
|
None of the differences were statistically significant; *known serum creatinine >3.39 mg/dl; SD, standard deviation; SAPS II, simplified acute physiology score; SOFA, sequential organ failure assessment; HES, hydroxyethyl starch; NaCI, sodium chloride. |
||
|
Guidet et al. Critical Care 2012 16:R94 doi:10.1186/cc11358 |
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