Table 2 |
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|
Plasma concentrations of biomarkers and severity scores, by sepsis severity |
|||||||
|
Biomarker or severity scoring system |
All (n = 107) |
Severe sepsis (n = 33) |
Septic shock (n = 74) |
||||
|
Median |
IQR |
Median |
IQR |
Median |
IQR |
Test |
|
|
|
|||||||
|
Acute-phase proteins |
|||||||
|
CRP, mg/L |
253.5 |
155.5 |
218 |
152 |
266 |
158 |
0.35 |
|
PCT, ng/mL |
25.12 |
48.98 |
11.96 |
20.94 |
39.25 |
49.99 |
< 0.0001 |
|
PSP/reg, ng/mL |
241.25 |
399.00 |
73.5 |
180.25 |
343.5 |
369 |
< 0.0001 |
|
Cytokines |
|||||||
|
TNF-α, pg/ml |
2.47 |
7.07 |
1.93 |
7.07 |
2.41 |
6.97 |
0.86 |
|
IL-1β, pg/mL |
6.43 |
21.04 |
1.96 |
15.53 |
8.175 |
24.54 |
0.21 |
|
IL-6, pg/mL |
1,173.28 |
6,749.6 |
544.07 |
1,237.48 |
1,755.34 |
14,514.13 |
0.004 |
|
IL-8, pg/mL |
438.95 |
1,804.67 |
184.15 |
408.72 |
681.775 |
3,273.42 |
0.0001 |
|
IL-10, pg/mL |
149.37 |
672.82 |
76.24 |
239.67 |
199.94 |
706.22 |
0.045 |
|
Other |
|||||||
|
Leukocytes, G/L |
13.5 |
14.2 |
13.5 |
5.5 |
13.3 |
17.1 |
0.28 |
|
APACHE II |
28 |
14 |
26 |
14 |
29 |
14 |
0.04 |
|
SAPS II |
69 |
26 |
62 |
29 |
71 |
27 |
0.02 |
|
SAPS III |
76 |
27 |
69 |
28 |
79.5 |
25 |
0.001 |
|
SOFA |
11 |
4 |
10 |
5 |
11 |
5 |
0.35 |
|
|
|||||||
|
APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein; IL, interleukin; IQR, interquartile range; PCT, procalcitonin; PSP/reg, pancreatic stone protein/regenerating protein; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; TNF-α, tumor necrosis factor-alpha. |
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|
Que et al. Critical Care 2012 16:R114 doi:10.1186/cc11406 |
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