Critical Care | Volume 16 Issue 5

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	Volume 16 Issue 5
	Comment
	Editorial Indexed hemodynamic measurements may be inappropriate at body surface area extremes Adam C Adler, Brian H Nathanson, Karthik Raghunathan, William T McGee Critical Care 2012, 16:149 (4 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Increasing awareness of sepsis: World Sepsis Day Jean-Louis Vincent Critical Care 2012, 16:152 (13 September 2012) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Erythropoietin in the critically ill: do we ask the right questions? Oscar McCook, Michael Georgieff, Angelika Scheuerle, Peter Möller, Christoph Thiemermann, Peter Radermacher Critical Care 2012, 16:319 (26 September 2012) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Oxygen-induced hypercapnia in COPD: myths and facts Wilson F Abdo, Leo MA Heunks Critical Care 2012, 16:323 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary On the origins of lactate during sepsis Sébastien Gibot Critical Care 2012, 16:151 (10 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary During critical illness the gut does not pass the acid test John C Alverdy Critical Care 2012, 16:150 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Anemia, red blood cell transfusion, and outcomes after severe traumatic brain injury Derek J Roberts, David A Zygun Critical Care 2012, 16:154 (14 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Regional citrate anticoagulation in patients with liver failure - time for a rethink? Sameer Patel, Julia Wendon Critical Care 2012, 16:153 (17 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary The risks and rewards of expanding ICU capacity Jeremy M Kahn Critical Care 2012, 16:156 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Statins in pneumonia - magic versus science? Peter S Kruger, Robert M Thomas Critical Care 2012, 16:157 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Hypothermia in trauma patients: predicting the big chill Brett H Waibel Critical Care 2012, 16:155 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet Bruce A Molitoris Critical Care 2012, 16:158 (24 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Validating scores: a good business for a trauma register Marcus R Raum Critical Care 2012, 16:159 (28 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary New conclusive data on human myocardial dysfunction induced by acidosis Antoine Kimmoun, Nicolas Ducrocq, Bruno Levy Critical Care 2012, 16:160 (28 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised? Zbigniew Zasłona, Marc Peters-Golden Critical Care 2012, 16:161 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Metformin overdose: time to move on Jean-Christophe Orban, Eric Fontaine, Carole Ichai Critical Care 2012, 16:164 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Airway management disasters in the ICU - lessons learned? Christian Byhahn, Erol Cavus Critical Care 2012, 16:162 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Optimal glycemic control in neurocritical care patients Federico Bilotta, Giovanni Rosa Critical Care 2012, 16:163 (30 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Advancing the science of ventilator-associated pneumonia surveillance Michael Klompas Critical Care 2012, 16:165 (31 October 2012) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Clinical review: Biomarkers of acute kidney injury: where are we now? Marlies Ostermann, Barbara J Philips, Lui G Forni Critical Care 2012, 16:233 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Review Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future Matthew E Cove, Graeme MacLaren, William J Federspiel, John A Kellum Critical Care 2012, 16:232 (21 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: An approach to hemodynamic monitoring - Guyton at the bedside Sheldon Magder Critical Care 2012, 16:236 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Review Clinical review: The liver in sepsis Nicolas Nesseler, Yoann Launey, Caroline Aninat, Fabrice Morel, Yannick Mallédant, Philippe Seguin Critical Care 2012, 16:235 (30 October 2012) Abstract \| Full text \| PDF \| PubMed
	Report
	Journal club critique Weighing risks and benefits of stress ulcer prophylaxis in critically ill patients Trupesh Chanpura, Sachin Yende Critical Care 2012, 16:322 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Correction Correction: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group, Byung Lee, Daisuke Inui, Gee Suh, Jae Kim, Jae Kwon, Jisook Park, Keiichi Tada, Keiji Tanaka, Kenichi Ietsugu, Kenji Uehara, Kentaro Dote, Kimitaka Tajimi, Kiyoshi Morita, Koichi Matsuo, Koji Hoshino, Koji Hosokawa, Kook Lee, Kyoung Lee, Makoto Takatori, Masaji Nishimura, Masamitsu Sanui, Masanori Ito, Moritoki Egi, Naofumi Honda, Naoko Okayama, Nobuaki Shime, Ryosuke Tsuruta, Satoshi Nogami, Seok-Hwa Yoon et al. Critical Care 2012, 16:450 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Correction Correction: Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts Vedat Schwenger, Markus A Weigand, Oskar Hoffmann, Ralf Dikow, Lars P Kihm, Jörg Seckinger, Nexhat Miftari, Matthias Schaier, Stefan Hofer, Caroline Haar, Peter P Nawroth, Martin Zeier, Eike Martin, Christian Morath Critical Care 2012, 16:451 (31 October 2012) Abstract \| Full text \| PDF \| PubMed
	Book report Acute Exacerbations of Respiratory Diseases Michael R Pinsky Critical Care 2012, 16:320 (24 October 2012) Abstract \| Full text \| PDF
	Book report Essential anesthesia. From science to practice Robert Tircoveanu, Philippe Van der Linden Critical Care 2012, 16:321 (26 October 2012) Abstract \| Full text \| PDF
	Research
	Research Choice of hospital after out-of-hospital cardiac arrest - a decision with far-reaching consequences: a study in a large German city Jan Wnent, Stephan Seewald, Matthias Heringlake, Hans Lemke, Kirk Brauer, Rolf Lefering, Matthias Fischer, Tanja Jantzen, Berthold Bein, Martin Messelken, Jan-Thorsten Gräsner Critical Care 2012, 16:R164 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	Research Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury Antoine Dewitte, Julien Coquin, Bertrand Meyssignac, Olivier Joannès-Boyau, Catherine Fleureau, Hadrien Roze, Jean Ripoche, Gérard Janvier, Christian Combe, Alexandre Ouattara Critical Care 2012, 16:R165 (12 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury Jan Rossaint, Jerry L Nadler, Klaus Ley, Alexander Zarbock Critical Care 2012, 16:R166 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Comparative effects on glucose absorption of intragastric and post-pyloric nutrient delivery in the critically ill Anna E Di Bartolomeo, Marianne J Chapman, Antony V Zaknic, Matthew J Summers, Karen L Jones, Nam Q Nguyen, Christopher K Rayner, Michael Horowitz, Adam M Deane Critical Care 2012, 16:R167 (17 September 2012) Abstract \| Full text \| PDF \| PubMed
	Research Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis Daniela S Herzig, Yin Guo, Geping Fang, Tracy E Toliver-Kinsky, Edward R Sherwood Critical Care 2012, 16:R168 (19 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? a meta-analysis Yi Lin, Bin He, Jian Chen, Zhi Wang Critical Care 2012, 16:R169 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| F1000 Biology \| Editor’s summary The use of dexmedetomidine was associated with a shorter length of mechanical ventilation and lower risk of delirium following cardiac surgery, although bradycardia risk was significantly higher compared to traditional sedatives.
	Research Impact of emergency medical helicopter transport directly to a university hospital trauma center on mortality of severe blunt trauma patients until discharge Thibaut Desmettre, Jean-Michel Yeguiayan, Hervé Coadou, Claude Jacquot, Mathieu Raux, Benoit Vivien, Claude Martin, Claire Bonithon-Kopp, Marc Freysz, the French Intensive Care Recorded in Severe Trauma Critical Care 2012, 16:R170 (28 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Severely injured patients transported directly to hospital by helicopter have a lower risk of death than patients transported by road once the severity of their injuries are taken into account.
	Research Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome Takeshi Wada, Subrina Jesmin, Satoshi Gando, Yuichiro Yanagida, Asumi Mizugaki, Sayeeda N Sultana, Sohel Zaedi, Hiroyuki Yokota Critical Care 2012, 16:R171 (29 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Relation between proteinuria and acute kidney injury in patients with severe burns Jiong Hu, Xin Meng, Jian Han, Fei Xiang, Ya Fang, Jun Wu, Yi Peng, Ya Wu, Yue Huang, Qi Luo Critical Care 2012, 16:R172 (29 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research An observational study to determine the effect of delayed admission to the intensive care unit on patient outcome David JP O'Callaghan, Parveen Jayia, Eyston Vaughan-Huxley, Michael Gribbon, Maie Templeton, James RA Skipworth, Anthony C Gordon Critical Care 2012, 16:R173 (1 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research The pediatric sepsis biomarker risk model Hector R Wong, Shelia Salisbury, Qiang Xiao, Natalie Z Cvijanovich, Mark Hall, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Richard Lin, Thomas P Shanley, Michael T Bigham, Anita Sen, Jeffrey Nowak, Michael Quasney, Jared W Henricksen, Arun Chopra, Sharon Banschbach, Eileen Beckman, Kelli Harmon, Patrick Lahni, Christopher J Lindsell Critical Care 2012, 16:R174 (1 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A biomarker-based risk model to stratify pediatric septic shock outcomes reliably identifies children at risk of death and has potential applications for clinical trial stratification, patient decision-making, and quality assurance.
	Research Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data Richard Brunner, Gabriel Adelsmayr, Harald Herkner, Christian Madl, Ulrike Holzinger Critical Care 2012, 16:R175 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study Carlijn TI de Betue, Sascha CAT Verbruggen, Henk Schierbeek, Shaji K Chacko, Ad JJC Bogers, Johannes B van Goudoever, Koen FM Joosten Critical Care 2012, 16:R176 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Research Effects of respiratory mechanics on the capnogram phases: importance of dynamic compliance of the respiratory system Barna Babik, Zsófia Csorba, Dorottya Czövek, Patrick N Mayr, Gábor Bogáts, Ferenc Peták Critical Care 2012, 16:R177 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Oxygen deficit and H₂S in hemorrhagic shock in rats Andry Van de Louw, Philippe Haouzi Critical Care 2012, 16:R178 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Effect of non-clinical inter-hospital critical care unit to unit transfer of critically ill patients: a propensity-matched cohort analysis Helen Barratt, David A Harrison, Kathryn M Rowan, Rosalind Raine Critical Care 2012, 16:R179 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Adult patients transferred to other hospitals for non-clinical reasons received 3 additional days of critical care; indicating the need for further evidence to understand the effects of non-clinical transfer.
	Research Metformin overdose causes platelet mitochondrial dysfunction in humans Alessandro Protti, Anna Lecchi, Francesco Fortunato, Andrea Artoni, Noemi Greppi, Sarah Vecchio, Gigliola Fagiolari, Maurizio Moggio, Giacomo Comi, Giovanni Mistraletti, Barbara Lanticina, Loredana Faraldi, Luciano Gattinoni Critical Care 2012, 16:R180 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Human platelets exposed to a toxic dose of metformin show clear signs of mitochondrial dysfunction, such changes in other organs would likely contribute to the pathogenesis of metformin-induced lactic acidosis.
	Research Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium Patrick Schramm, Klaus Klein, Lena Falkenberg, Manfred Berres, Dorothea Closhen, Konrad J Werhahn, Matthias David, Christian Werner, Kristin Engelhard Critical Care 2012, 16:R181 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| F1000 Biology
	Research Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis Alessio Alfieri, Jay J Watson, Richard A Kammerer, Mohammed Tasab, Pavlos Progias, Kimberly Reeves, Nicola J Brown, Zoe L Brookes Critical Care 2012, 16:R182 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Identification of sepsis subtypes in critically ill adults using gene expression profiling David M Maslove, Benjamin M Tang, Anthony S McLean Critical Care 2012, 16:R183 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a meta-analysis Lorenzo Pradelli, Konstantin Mayer, Maurizio Muscaritoli, Axel R Heller Critical Care 2012, 16:R184 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Reversal of Vitamin K Antagonist (VKA) effect in patients with severe bleeding: a French multicenter observational study (Optiplex) assessing the use of Prothrombin Complex Concentrate (PCC) in current clinical practice Thibaut Desmettre, Emilie Dehours, Charles-Marc Samama, Suchin Jhundoo, Frédéric Pujeau, Christian Guillaudin, Claudine Hecquart, Pierre Clerson, Jean Crave, Roland Jaussaud Critical Care 2012, 16:R185 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Hypertonic saline reduces lipopolysaccharide-induced mouse brain edema through inhibiting aquaporin 4 expression Cao C, Yu X, Liao Z, Zhu N, Huo H, Wang M, Ji G, She H, Luo Z, Yue S Critical Care 2012, 16:R186 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Blood levels of copeptin on admission predict outcomes in out-of-hospital cardiac arrest survivors treated with therapeutic hypothermia Petr Ostadal, Andreas Kruger, Vladimira Zdrahalova, Marek Janotka, Dagmar Vondrakova, Petr Neuzil, Miroslav Prucha Critical Care 2012, 16:R187 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: need for a cautious use Laurent Muller, Xavier Bobbia, Mehdi Toumi, Guillaume Louart, Nicolas Molinari, Benoit Ragonnet, Hervé Quintard, Marc Leone, Lana Zoric, Jean Lefrant, the AzuRea group Critical Care 2012, 16:R188 (8 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study Sunghoon Park, Dong-Gyu Kim, Gee Suh, Jun Kang, Young-Su Ju, Yong-Jae Lee, Ji Park, Seok Lee, Ki-Suck Jung Critical Care 2012, 16:R189 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Impact of oral care with versus without toothbrushing on the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials Wan-Jie Gu, Yi-Zhen Gong, Lei Pan, Yu-Xia Ni, Jing-Chen Liu Critical Care 2012, 16:R190 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Late pharmacologic conditioning with volatile anesthetics after cardiac surgery Marc P Steurer, Martina A Steurer, Werner Baulig, Tobias Piegeler, Martin Schläpfer, Donat R Spahn, Volkmar Falk, Pamela Dreessen, Oliver M Theusinger, Edith R Schmid, David Schwartz, Thomas A Neff, Beatrice Beck-Schimmer Critical Care 2012, 16:R191 (14 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study Dorothy M Wade, David C Howell, John A Weinman, Rebecca J Hardy, Michael G Mythen, Chris R Brewin, Susana Borja-Boluda, Claire F Matejowsky, Rosalind A Raine Critical Care 2012, 16:R192 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients experiencing acute psychological reactions in the intensive care unit (ICU) were found to be at an increased risk of developing mental illness after recovery; suggesting interventions during treatment could reduce psychological morbidity in ICU survivors.
	Research The relationship between serum sodium and intracranial pressure when using hypertonic saline to target mild hypernatremia in patients with head trauma Diana L Wells, Joseph M Swanson, G Christopher Wood, Louis J Magnotti, Bradley A Boucher, Martin A Croce, Charles G Harrison, Michael S Muhlbauer, Timothy C Fabian Critical Care 2012, 16:R193 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation Kiran Shekar, Jason A Roberts, Charles I Mcdonald, Stephanie Fisquet, Adrian G Barnett, Daniel V Mullany, Sussan Ghassabian, Steven C Wallis, Yoke L Fung, Maree T Smith, John F Fraser Critical Care 2012, 16:R194 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Complication rates as a trauma care performance indicator: a systematic review Lynne Moore, Henry Stelfox, Alexis F Turgeon Critical Care 2012, 16:R195 (16 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study Suvi T Vaara, Anna-Maija Korhonen, Kirsi-Maija Kaukonen, Sara Nisula, Outi Inkinen, Sanna Hoppu, Jouko J Laurila, Leena Mildh, Matti Reinikainen, Vesa Lund, Ilkka Parviainen, Ville Pettilä, The FINNAKI study group Critical Care 2012, 16:R197 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Endothelin-receptor antagonists for aneurysmal subarachnoid hemorrhage: an updated meta-analysis of randomized controlled trials Junpeng Ma, Siqing Huang, Lu Ma, Yi Liu, Hao Li, Chao You Critical Care 2012, 16:R198 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Protective effects of aerobic exercise on acute lung injury induced by LPS in mice Cintia Reis Gonçalves, Carlos Reis Gonçalves, Francine de Almeida, Fernanda dos Santos Lopes, Ana dos Santos Durão, Fabiana dos Santos, Luiz da Silva, Tania Marcourakis, Hugo C Castro-Faria-Neto, Rodolfo Vieira, Marisa Dolhnikoff Critical Care 2012, 16:R199 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients Kama A Wlodzimirow, Ameen Abu-Hanna, Mathilde Slabbekoorn, Robert AFM Chamuleau, Marcus J Schultz, Catherine SC Bouman Critical Care 2012, 16:R200 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Influence of prehospital volume replacement on outcome in polytraumatized children Bjoern Hussmann, Rolf Lefering, Max Kauther, Steffen Ruchholtz, Patrick Moldzio, Sven Lendemans, the TraumaRegister DGU® Critical Care 2012, 16:R201 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia Carol L Hodgson, Kate Hayes, Tori Everard, Alistair Nichol, Andrew R Davies, Michael J Bailey, David V Tuxen, David J Cooper, Vin Pellegrino Critical Care 2012, 16:R202 (19 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis Andreas H Kramer, Derek J Roberts, David A Zygun Critical Care 2012, 16:R203 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Intensive glycemic control does not reduce mortality in neurocritical care patients and might lead to increased neurological damage, therefore maintaining intermediate glucose levels may be the optimal strategy in such patients.
	Research Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis Michael Adamzik, Klaus Görlinger, Jürgen Peters, Matthias Hartmann Critical Care 2012, 16:R204 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project Ron Wald, Jan O Friedrich, Sean M Bagshaw, Karen EA Burns, Amit X Garg, Michelle A Hladunewich, Andrew A House, Stephen Lapinsky, David Klein, Neesh I Pannu, Karen Pope, Robert M Richardson, Kevin Thorpe, Neill KJ Adhikari Critical Care 2012, 16:R205 (24 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Research Toll-like receptors expression and interferon-γ production by NK cells in human sepsis Fernando Souza-Fonseca-Guimaraes, Marianna Parlato, François Philippart, Benoît Misset, Jean-Marc Cavaillon, Minou Adib-Conquy, the Captain study group Critical Care 2012, 16:R206 (25 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Empirical use of fluoroquinolones improves the survival of critically ill patients with tuberculosis mimicking severe pneumonia Yu-Tzu Tseng, Yu-Chung Chuang, Chin-Chung Shu, Chien-Ching Hung, Chiung-Fang Hsu, Jann-Yuan Wang Critical Care 2012, 16:R207 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Matching positive end-expiratory pressure to intra-abdominal pressure improves oxygenation in a porcine sick lung model of intra-abdominal hypertension Adrian Regli, Rohan Mahendran, Edward T Fysh, Brigit Roberts, Bill Noffsinger, Bart L De Keulenaer, Bhajan Singh, Peter V van Heerden Critical Care 2012, 16:R208 (26 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Studies in a pig model support the application of positive-end expiratory pressure (PEEP) in acute lung injury with intra-abdominal hypertension.
	Research Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading Monica Llano-Diez, Guillaume Renaud, Magnus Andersson, Humberto Marrero, Nicola Cacciani, Henrik Engquist, Rebeca Corpeño, Konstantin Artemenko, Jonas Bergquist, Lars Larsson Critical Care 2012, 16:R209 (26 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Potential impact of propofol immediately after motor vehicle accident on later symptoms of posttraumatic stress disorder at 6-month follow up: a retrospective cohort study Masato Usuki, Yutaka Matsuoka, Daisuke Nishi, Naohiro Yonemoto, Kenta Matsumura, Yasuhiro Otomo, Yoshiharu Kim, Shigenobu Kanba Critical Care 2012, 16:R196 (28 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The administration of the sedative propofol after trauma may be associated with an increase in posttraumatic stress disorder (PTSD) symptoms 6 months after the incident, potentially due to enhanced fear memory consolidation.
	Research Medical emergency teams are associated with reduced mortality across a major metropolitan health network after two years service: a retrospective study using government administrative data Antony E Tobin, John D Santamaria Critical Care 2012, 16:R210 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Polymorphic variants in exon 8 at the 3' UTR of the HLA-G gene are associated with septic shock in critically ill patients Pietra Graebin, Tiago D Veit, Clarice S Alho, Fernando S Dias, José AB Chies Critical Care 2012, 16:R211 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A polymorphism in the 3' UTR of the human leukocyte antigen G (HLA-G) gene is associated with an increased risk for septic shock in critically ill patients.
	Research The estimation of cardiac output by the Nexfin device is of poor reliability for tracking the effects of a fluid challenge Xavier Monnet, Fabien Picard, Elsa Lidzborski, Malcie Mesnil, Jacques Duranteau, Christian Richard, Jean-Louis Teboul Critical Care 2012, 16:R212 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children Hector R Wong, Natalie Z Cvijanovich, Mark Hall, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Richard Lin, Michael T Bigham, Anita Sen, Jeffrey Nowak, Michael Quasney, Jared W Henricksen, Arun Chopra, Sharon Banschbach, Eileen Beckman, Kelli Harmon, Patrick Lahni, Thomas P Shanley Critical Care 2012, 16:R213 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Medical-grade honey does not reduce skin colonization at central venous catheter-insertion sites of critically ill patients: a randomized controlled trial Paulus H Kwakman, Marcella C Müller, Jan M Binnekade, Johannes P van den Akker, Corianne A de Borgie, Marcus J Schultz, Sebastian A Zaat Critical Care 2012, 16:R214 (30 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Correspondence
	Letter Number needed to treat for subglottic secretion drainage technology as a ventilator-associated pneumonia prevention strategy Scott D Kelley Critical Care 2012, 16:446 (4 September 2012) Abstract \| Full text \| PDF \| PubMed
	Letter Potential for overuse of corticosteroids and vasopressin in septic shock Joe L Hsu, Vincent Liu, Andrew J Patterson, Greg S Martin, Mark R Nicolls, James A Russell Critical Care 2012, 16:447 (6 September 2012) Abstract \| Full text \| PDF \| PubMed
	Letter Concerns regarding use of one-tailed tests in the SLED-BD vs. CVVH trial Gordon S Doig Critical Care 2012, 16:448 (14 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Cardiopulmonary resuscitation after traumatic cardiac arrest - there are survivors: registries must speak about it Adriano Peris, Simona Biondi, Giovanni Zagli Critical Care 2012, 16:449 (21 September 2012) Abstract \| Full text \| PDF \| PubMed

	Volume 16 Issue 5
	Comment
	Editorial Indexed hemodynamic measurements may be inappropriate at body surface area extremes Adam C Adler, Brian H Nathanson, Karthik Raghunathan, William T McGee Critical Care 2012, 16:149 (4 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Increasing awareness of sepsis: World Sepsis Day Jean-Louis Vincent Critical Care 2012, 16:152 (13 September 2012) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Erythropoietin in the critically ill: do we ask the right questions? Oscar McCook, Michael Georgieff, Angelika Scheuerle, Peter Möller, Christoph Thiemermann, Peter Radermacher Critical Care 2012, 16:319 (26 September 2012) Abstract \| Full text \| PDF \| PubMed
	Viewpoint Oxygen-induced hypercapnia in COPD: myths and facts Wilson F Abdo, Leo MA Heunks Critical Care 2012, 16:323 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary On the origins of lactate during sepsis Sébastien Gibot Critical Care 2012, 16:151 (10 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary During critical illness the gut does not pass the acid test John C Alverdy Critical Care 2012, 16:150 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Anemia, red blood cell transfusion, and outcomes after severe traumatic brain injury Derek J Roberts, David A Zygun Critical Care 2012, 16:154 (14 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Regional citrate anticoagulation in patients with liver failure - time for a rethink? Sameer Patel, Julia Wendon Critical Care 2012, 16:153 (17 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary The risks and rewards of expanding ICU capacity Jeremy M Kahn Critical Care 2012, 16:156 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Statins in pneumonia - magic versus science? Peter S Kruger, Robert M Thomas Critical Care 2012, 16:157 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Hypothermia in trauma patients: predicting the big chill Brett H Waibel Critical Care 2012, 16:155 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet Bruce A Molitoris Critical Care 2012, 16:158 (24 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Validating scores: a good business for a trauma register Marcus R Raum Critical Care 2012, 16:159 (28 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary New conclusive data on human myocardial dysfunction induced by acidosis Antoine Kimmoun, Nicolas Ducrocq, Bruno Levy Critical Care 2012, 16:160 (28 September 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised? Zbigniew Zasłona, Marc Peters-Golden Critical Care 2012, 16:161 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Metformin overdose: time to move on Jean-Christophe Orban, Eric Fontaine, Carole Ichai Critical Care 2012, 16:164 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Airway management disasters in the ICU - lessons learned? Christian Byhahn, Erol Cavus Critical Care 2012, 16:162 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Optimal glycemic control in neurocritical care patients Federico Bilotta, Giovanni Rosa Critical Care 2012, 16:163 (30 October 2012) Abstract \| Full text \| PDF \| PubMed
	Commentary Advancing the science of ventilator-associated pneumonia surveillance Michael Klompas Critical Care 2012, 16:165 (31 October 2012) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Clinical review: Biomarkers of acute kidney injury: where are we now? Marlies Ostermann, Barbara J Philips, Lui G Forni Critical Care 2012, 16:233 (21 September 2012) Abstract \| Full text \| PDF \| PubMed
	Review Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future Matthew E Cove, Graeme MacLaren, William J Federspiel, John A Kellum Critical Care 2012, 16:232 (21 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: An approach to hemodynamic monitoring - Guyton at the bedside Sheldon Magder Critical Care 2012, 16:236 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Review Clinical review: The liver in sepsis Nicolas Nesseler, Yoann Launey, Caroline Aninat, Fabrice Morel, Yannick Mallédant, Philippe Seguin Critical Care 2012, 16:235 (30 October 2012) Abstract \| Full text \| PDF \| PubMed
	Report
	Journal club critique Weighing risks and benefits of stress ulcer prophylaxis in critically ill patients Trupesh Chanpura, Sachin Yende Critical Care 2012, 16:322 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Correction Correction: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group, Byung Lee, Daisuke Inui, Gee Suh, Jae Kim, Jae Kwon, Jisook Park, Keiichi Tada, Keiji Tanaka, Kenichi Ietsugu, Kenji Uehara, Kentaro Dote, Kimitaka Tajimi, Kiyoshi Morita, Koichi Matsuo, Koji Hoshino, Koji Hosokawa, Kook Lee, Kyoung Lee, Makoto Takatori, Masaji Nishimura, Masamitsu Sanui, Masanori Ito, Moritoki Egi, Naofumi Honda, Naoko Okayama, Nobuaki Shime, Ryosuke Tsuruta, Satoshi Nogami, Seok-Hwa Yoon et al. Critical Care 2012, 16:450 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Correction Correction: Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts Vedat Schwenger, Markus A Weigand, Oskar Hoffmann, Ralf Dikow, Lars P Kihm, Jörg Seckinger, Nexhat Miftari, Matthias Schaier, Stefan Hofer, Caroline Haar, Peter P Nawroth, Martin Zeier, Eike Martin, Christian Morath Critical Care 2012, 16:451 (31 October 2012) Abstract \| Full text \| PDF \| PubMed
	Book report Acute Exacerbations of Respiratory Diseases Michael R Pinsky Critical Care 2012, 16:320 (24 October 2012) Abstract \| Full text \| PDF
	Book report Essential anesthesia. From science to practice Robert Tircoveanu, Philippe Van der Linden Critical Care 2012, 16:321 (26 October 2012) Abstract \| Full text \| PDF
	Research
	Research Choice of hospital after out-of-hospital cardiac arrest - a decision with far-reaching consequences: a study in a large German city Jan Wnent, Stephan Seewald, Matthias Heringlake, Hans Lemke, Kirk Brauer, Rolf Lefering, Matthias Fischer, Tanja Jantzen, Berthold Bein, Martin Messelken, Jan-Thorsten Gräsner Critical Care 2012, 16:R164 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	Research Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury Antoine Dewitte, Julien Coquin, Bertrand Meyssignac, Olivier Joannès-Boyau, Catherine Fleureau, Hadrien Roze, Jean Ripoche, Gérard Janvier, Christian Combe, Alexandre Ouattara Critical Care 2012, 16:R165 (12 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury Jan Rossaint, Jerry L Nadler, Klaus Ley, Alexander Zarbock Critical Care 2012, 16:R166 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Comparative effects on glucose absorption of intragastric and post-pyloric nutrient delivery in the critically ill Anna E Di Bartolomeo, Marianne J Chapman, Antony V Zaknic, Matthew J Summers, Karen L Jones, Nam Q Nguyen, Christopher K Rayner, Michael Horowitz, Adam M Deane Critical Care 2012, 16:R167 (17 September 2012) Abstract \| Full text \| PDF \| PubMed
	Research Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis Daniela S Herzig, Yin Guo, Geping Fang, Tracy E Toliver-Kinsky, Edward R Sherwood Critical Care 2012, 16:R168 (19 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? a meta-analysis Yi Lin, Bin He, Jian Chen, Zhi Wang Critical Care 2012, 16:R169 (27 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| F1000 Biology \| Editor’s summary The use of dexmedetomidine was associated with a shorter length of mechanical ventilation and lower risk of delirium following cardiac surgery, although bradycardia risk was significantly higher compared to traditional sedatives.
	Research Impact of emergency medical helicopter transport directly to a university hospital trauma center on mortality of severe blunt trauma patients until discharge Thibaut Desmettre, Jean-Michel Yeguiayan, Hervé Coadou, Claude Jacquot, Mathieu Raux, Benoit Vivien, Claude Martin, Claire Bonithon-Kopp, Marc Freysz, the French Intensive Care Recorded in Severe Trauma Critical Care 2012, 16:R170 (28 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Severely injured patients transported directly to hospital by helicopter have a lower risk of death than patients transported by road once the severity of their injuries are taken into account.
	Research Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome Takeshi Wada, Subrina Jesmin, Satoshi Gando, Yuichiro Yanagida, Asumi Mizugaki, Sayeeda N Sultana, Sohel Zaedi, Hiroyuki Yokota Critical Care 2012, 16:R171 (29 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Relation between proteinuria and acute kidney injury in patients with severe burns Jiong Hu, Xin Meng, Jian Han, Fei Xiang, Ya Fang, Jun Wu, Yi Peng, Ya Wu, Yue Huang, Qi Luo Critical Care 2012, 16:R172 (29 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research An observational study to determine the effect of delayed admission to the intensive care unit on patient outcome David JP O'Callaghan, Parveen Jayia, Eyston Vaughan-Huxley, Michael Gribbon, Maie Templeton, James RA Skipworth, Anthony C Gordon Critical Care 2012, 16:R173 (1 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research The pediatric sepsis biomarker risk model Hector R Wong, Shelia Salisbury, Qiang Xiao, Natalie Z Cvijanovich, Mark Hall, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Richard Lin, Thomas P Shanley, Michael T Bigham, Anita Sen, Jeffrey Nowak, Michael Quasney, Jared W Henricksen, Arun Chopra, Sharon Banschbach, Eileen Beckman, Kelli Harmon, Patrick Lahni, Christopher J Lindsell Critical Care 2012, 16:R174 (1 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A biomarker-based risk model to stratify pediatric septic shock outcomes reliably identifies children at risk of death and has potential applications for clinical trial stratification, patient decision-making, and quality assurance.
	Research Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data Richard Brunner, Gabriel Adelsmayr, Harald Herkner, Christian Madl, Ulrike Holzinger Critical Care 2012, 16:R175 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study Carlijn TI de Betue, Sascha CAT Verbruggen, Henk Schierbeek, Shaji K Chacko, Ad JJC Bogers, Johannes B van Goudoever, Koen FM Joosten Critical Care 2012, 16:R176 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Research Effects of respiratory mechanics on the capnogram phases: importance of dynamic compliance of the respiratory system Barna Babik, Zsófia Csorba, Dorottya Czövek, Patrick N Mayr, Gábor Bogáts, Ferenc Peták Critical Care 2012, 16:R177 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Oxygen deficit and H₂S in hemorrhagic shock in rats Andry Van de Louw, Philippe Haouzi Critical Care 2012, 16:R178 (2 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Effect of non-clinical inter-hospital critical care unit to unit transfer of critically ill patients: a propensity-matched cohort analysis Helen Barratt, David A Harrison, Kathryn M Rowan, Rosalind Raine Critical Care 2012, 16:R179 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Adult patients transferred to other hospitals for non-clinical reasons received 3 additional days of critical care; indicating the need for further evidence to understand the effects of non-clinical transfer.
	Research Metformin overdose causes platelet mitochondrial dysfunction in humans Alessandro Protti, Anna Lecchi, Francesco Fortunato, Andrea Artoni, Noemi Greppi, Sarah Vecchio, Gigliola Fagiolari, Maurizio Moggio, Giacomo Comi, Giovanni Mistraletti, Barbara Lanticina, Loredana Faraldi, Luciano Gattinoni Critical Care 2012, 16:R180 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Human platelets exposed to a toxic dose of metformin show clear signs of mitochondrial dysfunction, such changes in other organs would likely contribute to the pathogenesis of metformin-induced lactic acidosis.
	Research Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium Patrick Schramm, Klaus Klein, Lena Falkenberg, Manfred Berres, Dorothea Closhen, Konrad J Werhahn, Matthias David, Christian Werner, Kristin Engelhard Critical Care 2012, 16:R181 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| F1000 Biology
	Research Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis Alessio Alfieri, Jay J Watson, Richard A Kammerer, Mohammed Tasab, Pavlos Progias, Kimberly Reeves, Nicola J Brown, Zoe L Brookes Critical Care 2012, 16:R182 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Identification of sepsis subtypes in critically ill adults using gene expression profiling David M Maslove, Benjamin M Tang, Anthony S McLean Critical Care 2012, 16:R183 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a meta-analysis Lorenzo Pradelli, Konstantin Mayer, Maurizio Muscaritoli, Axel R Heller Critical Care 2012, 16:R184 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Reversal of Vitamin K Antagonist (VKA) effect in patients with severe bleeding: a French multicenter observational study (Optiplex) assessing the use of Prothrombin Complex Concentrate (PCC) in current clinical practice Thibaut Desmettre, Emilie Dehours, Charles-Marc Samama, Suchin Jhundoo, Frédéric Pujeau, Christian Guillaudin, Claudine Hecquart, Pierre Clerson, Jean Crave, Roland Jaussaud Critical Care 2012, 16:R185 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Hypertonic saline reduces lipopolysaccharide-induced mouse brain edema through inhibiting aquaporin 4 expression Cao C, Yu X, Liao Z, Zhu N, Huo H, Wang M, Ji G, She H, Luo Z, Yue S Critical Care 2012, 16:R186 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Blood levels of copeptin on admission predict outcomes in out-of-hospital cardiac arrest survivors treated with therapeutic hypothermia Petr Ostadal, Andreas Kruger, Vladimira Zdrahalova, Marek Janotka, Dagmar Vondrakova, Petr Neuzil, Miroslav Prucha Critical Care 2012, 16:R187 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: need for a cautious use Laurent Muller, Xavier Bobbia, Mehdi Toumi, Guillaume Louart, Nicolas Molinari, Benoit Ragonnet, Hervé Quintard, Marc Leone, Lana Zoric, Jean Lefrant, the AzuRea group Critical Care 2012, 16:R188 (8 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study Sunghoon Park, Dong-Gyu Kim, Gee Suh, Jun Kang, Young-Su Ju, Yong-Jae Lee, Ji Park, Seok Lee, Ki-Suck Jung Critical Care 2012, 16:R189 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Impact of oral care with versus without toothbrushing on the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials Wan-Jie Gu, Yi-Zhen Gong, Lei Pan, Yu-Xia Ni, Jing-Chen Liu Critical Care 2012, 16:R190 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Late pharmacologic conditioning with volatile anesthetics after cardiac surgery Marc P Steurer, Martina A Steurer, Werner Baulig, Tobias Piegeler, Martin Schläpfer, Donat R Spahn, Volkmar Falk, Pamela Dreessen, Oliver M Theusinger, Edith R Schmid, David Schwartz, Thomas A Neff, Beatrice Beck-Schimmer Critical Care 2012, 16:R191 (14 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	Research Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study Dorothy M Wade, David C Howell, John A Weinman, Rebecca J Hardy, Michael G Mythen, Chris R Brewin, Susana Borja-Boluda, Claire F Matejowsky, Rosalind A Raine Critical Care 2012, 16:R192 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patients experiencing acute psychological reactions in the intensive care unit (ICU) were found to be at an increased risk of developing mental illness after recovery; suggesting interventions during treatment could reduce psychological morbidity in ICU survivors.
	Research The relationship between serum sodium and intracranial pressure when using hypertonic saline to target mild hypernatremia in patients with head trauma Diana L Wells, Joseph M Swanson, G Christopher Wood, Louis J Magnotti, Bradley A Boucher, Martin A Croce, Charles G Harrison, Michael S Muhlbauer, Timothy C Fabian Critical Care 2012, 16:R193 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation Kiran Shekar, Jason A Roberts, Charles I Mcdonald, Stephanie Fisquet, Adrian G Barnett, Daniel V Mullany, Sussan Ghassabian, Steven C Wallis, Yoke L Fung, Maree T Smith, John F Fraser Critical Care 2012, 16:R194 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Complication rates as a trauma care performance indicator: a systematic review Lynne Moore, Henry Stelfox, Alexis F Turgeon Critical Care 2012, 16:R195 (16 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study Suvi T Vaara, Anna-Maija Korhonen, Kirsi-Maija Kaukonen, Sara Nisula, Outi Inkinen, Sanna Hoppu, Jouko J Laurila, Leena Mildh, Matti Reinikainen, Vesa Lund, Ilkka Parviainen, Ville Pettilä, The FINNAKI study group Critical Care 2012, 16:R197 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Endothelin-receptor antagonists for aneurysmal subarachnoid hemorrhage: an updated meta-analysis of randomized controlled trials Junpeng Ma, Siqing Huang, Lu Ma, Yi Liu, Hao Li, Chao You Critical Care 2012, 16:R198 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Protective effects of aerobic exercise on acute lung injury induced by LPS in mice Cintia Reis Gonçalves, Carlos Reis Gonçalves, Francine de Almeida, Fernanda dos Santos Lopes, Ana dos Santos Durão, Fabiana dos Santos, Luiz da Silva, Tania Marcourakis, Hugo C Castro-Faria-Neto, Rodolfo Vieira, Marisa Dolhnikoff Critical Care 2012, 16:R199 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients Kama A Wlodzimirow, Ameen Abu-Hanna, Mathilde Slabbekoorn, Robert AFM Chamuleau, Marcus J Schultz, Catherine SC Bouman Critical Care 2012, 16:R200 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Influence of prehospital volume replacement on outcome in polytraumatized children Bjoern Hussmann, Rolf Lefering, Max Kauther, Steffen Ruchholtz, Patrick Moldzio, Sven Lendemans, the TraumaRegister DGU® Critical Care 2012, 16:R201 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia Carol L Hodgson, Kate Hayes, Tori Everard, Alistair Nichol, Andrew R Davies, Michael J Bailey, David V Tuxen, David J Cooper, Vin Pellegrino Critical Care 2012, 16:R202 (19 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis Andreas H Kramer, Derek J Roberts, David A Zygun Critical Care 2012, 16:R203 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Intensive glycemic control does not reduce mortality in neurocritical care patients and might lead to increased neurological damage, therefore maintaining intermediate glucose levels may be the optimal strategy in such patients.
	Research Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis Michael Adamzik, Klaus Görlinger, Jürgen Peters, Matthias Hartmann Critical Care 2012, 16:R204 (22 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project Ron Wald, Jan O Friedrich, Sean M Bagshaw, Karen EA Burns, Amit X Garg, Michelle A Hladunewich, Andrew A House, Stephen Lapinsky, David Klein, Neesh I Pannu, Karen Pope, Robert M Richardson, Kevin Thorpe, Neill KJ Adhikari Critical Care 2012, 16:R205 (24 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
	Research Toll-like receptors expression and interferon-γ production by NK cells in human sepsis Fernando Souza-Fonseca-Guimaraes, Marianna Parlato, François Philippart, Benoît Misset, Jean-Marc Cavaillon, Minou Adib-Conquy, the Captain study group Critical Care 2012, 16:R206 (25 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Empirical use of fluoroquinolones improves the survival of critically ill patients with tuberculosis mimicking severe pneumonia Yu-Tzu Tseng, Yu-Chung Chuang, Chin-Chung Shu, Chien-Ching Hung, Chiung-Fang Hsu, Jann-Yuan Wang Critical Care 2012, 16:R207 (25 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Matching positive end-expiratory pressure to intra-abdominal pressure improves oxygenation in a porcine sick lung model of intra-abdominal hypertension Adrian Regli, Rohan Mahendran, Edward T Fysh, Brigit Roberts, Bill Noffsinger, Bart L De Keulenaer, Bhajan Singh, Peter V van Heerden Critical Care 2012, 16:R208 (26 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Studies in a pig model support the application of positive-end expiratory pressure (PEEP) in acute lung injury with intra-abdominal hypertension.
	Research Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading Monica Llano-Diez, Guillaume Renaud, Magnus Andersson, Humberto Marrero, Nicola Cacciani, Henrik Engquist, Rebeca Corpeño, Konstantin Artemenko, Jonas Bergquist, Lars Larsson Critical Care 2012, 16:R209 (26 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Potential impact of propofol immediately after motor vehicle accident on later symptoms of posttraumatic stress disorder at 6-month follow up: a retrospective cohort study Masato Usuki, Yutaka Matsuoka, Daisuke Nishi, Naohiro Yonemoto, Kenta Matsumura, Yasuhiro Otomo, Yoshiharu Kim, Shigenobu Kanba Critical Care 2012, 16:R196 (28 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The administration of the sedative propofol after trauma may be associated with an increase in posttraumatic stress disorder (PTSD) symptoms 6 months after the incident, potentially due to enhanced fear memory consolidation.
	Research Medical emergency teams are associated with reduced mortality across a major metropolitan health network after two years service: a retrospective study using government administrative data Antony E Tobin, John D Santamaria Critical Care 2012, 16:R210 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Polymorphic variants in exon 8 at the 3' UTR of the HLA-G gene are associated with septic shock in critically ill patients Pietra Graebin, Tiago D Veit, Clarice S Alho, Fernando S Dias, José AB Chies Critical Care 2012, 16:R211 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A polymorphism in the 3' UTR of the human leukocyte antigen G (HLA-G) gene is associated with an increased risk for septic shock in critically ill patients.
	Research The estimation of cardiac output by the Nexfin device is of poor reliability for tracking the effects of a fluid challenge Xavier Monnet, Fabien Picard, Elsa Lidzborski, Malcie Mesnil, Jacques Duranteau, Christian Richard, Jean-Louis Teboul Critical Care 2012, 16:R212 (29 October 2012) Abstract \| Full text \| PDF \| PubMed
	Research Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children Hector R Wong, Natalie Z Cvijanovich, Mark Hall, Geoffrey L Allen, Neal J Thomas, Robert J Freishtat, Nick Anas, Keith Meyer, Paul A Checchia, Richard Lin, Michael T Bigham, Anita Sen, Jeffrey Nowak, Michael Quasney, Jared W Henricksen, Arun Chopra, Sharon Banschbach, Eileen Beckman, Kelli Harmon, Patrick Lahni, Thomas P Shanley Critical Care 2012, 16:R213 (29 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Medical-grade honey does not reduce skin colonization at central venous catheter-insertion sites of critically ill patients: a randomized controlled trial Paulus H Kwakman, Marcella C Müller, Jan M Binnekade, Johannes P van den Akker, Corianne A de Borgie, Marcus J Schultz, Sebastian A Zaat Critical Care 2012, 16:R214 (30 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Correspondence
	Letter Number needed to treat for subglottic secretion drainage technology as a ventilator-associated pneumonia prevention strategy Scott D Kelley Critical Care 2012, 16:446 (4 September 2012) Abstract \| Full text \| PDF \| PubMed
	Letter Potential for overuse of corticosteroids and vasopressin in septic shock Joe L Hsu, Vincent Liu, Andrew J Patterson, Greg S Martin, Mark R Nicolls, James A Russell Critical Care 2012, 16:447 (6 September 2012) Abstract \| Full text \| PDF \| PubMed
	Letter Concerns regarding use of one-tailed tests in the SLED-BD vs. CVVH trial Gordon S Doig Critical Care 2012, 16:448 (14 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Cardiopulmonary resuscitation after traumatic cardiac arrest - there are survivors: registries must speak about it Adriano Peris, Simona Biondi, Giovanni Zagli Critical Care 2012, 16:449 (21 September 2012) Abstract \| Full text \| PDF \| PubMed

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