Commentary
On the origins of lactate during sepsis
Service de Réanimation Médicale, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France
INSERM U961, Equipe TREM, Université de Lorraine, Faculté de Médecine, Nancy F-54000, France
Critical Care 2012, 16:151 doi:10.1186/cc11472
See related research by Michaeli et al., http://ccforum.com/content/16/4/R139
Published: 10 September 2012Abstract
The origins of sepsis-induced hyperlactatemia are still imperfectly understood and probably multifactorial, resulting both from an increased production by various tissues through aerobic and anaerobic glycolysis, and from a decreased lactate clearance. In the previous issue of Critical Care, Michaeli and colleagues showed that lactate elevation during mild endotoxemia is due to an increased aerobic production that does not take place in the muscle; other tissues/cells may thus be important contributors.
