Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet
Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Research Building #2, RM202, 950 West Walnut Street, Indianapolis, IN 46202, USA
Critical Care 2012, 16:158 doi:10.1186/cc11482
See related research by Pickering et al., http://ccforum.com/content/16/3/R107Published: 24 September 2012
Acute kidney injury has become a major focus for nephrologists and critical care physicians. The development of structural biomarkers is proceeding, but the results to date have been disappointing. The use of a shortened creatinine clearance as a functional acute kidney injury biomarker is not new but has not been compared with that of other diagnostic approaches. A rapid, repeatable, and accurate measured glomerular filtration rate would be the gold standard for a functional biomarker and is not far off.