New conclusive data on human myocardial dysfunction induced by acidosis
1 INSERM, Groupe Choc, contrat Avenir INSERM, U961, Faculté de Médecine, 54511 Vandoeuvre les Nancy, France
2 CHU Nancy, Service de Réanimation Médicale Brabois, Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois, 54511 Vandoeuvre les Nancy, France
3 Université de Lorraine, 54000 Nancy, France
Critical Care 2012, 16:160 doi:10.1186/cc11520
See related research by Schotola et al., http://ccforum.com/content/16/4/R153Published: 28 September 2012
Acidosis is one of the major consequences of hemodynamic instability in shock state patients directly associated with multiple organ failure evolution and death. Most studies on the hemodynamic consequences of acidosis have been experimental, nonhuman studies with severe acidosis, and thus far from the most common clinical situations. Schotola and colleagues offer a new approach to human failing myocardium where the authors highlight, ex vivo, the deleterious hemodynamic consequences of mild acidosis. Their work strengthens the current view of the urgent need to discover new efficient and nondeleterious therapy for the treatment of acidosis.