A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
Department of Internal Medicine, Division of Pulmonary and Critical Care, Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5642, USA
Critical Care 2012, 16:161 doi:10.1186/cc11519
See related research by Rossaint et al., http://ccforum.com/content/16/5/R166Published: 25 October 2012
New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.