CXCR3 blockade: a novel anti-sepsis approach?
Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida 32610, USA
Critical Care 2012, 16:176 doi:10.1186/cc11818
See related research by Herzig et al., http://ccforum.com/content/16/5/R168Published: 21 November 2012
Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed.