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Highly Accessed Commentary

Post-conditioning: Promising answers and more questions

David Bracco

Author Affiliations

Montreal General Hospital, Room D10-145-3, 1650 Cedar Avenue, McGill University, Montreal, QC, H3G 1A4, Canada

Critical Care 2012, 16:180  doi:10.1186/cc11850


See related research by Steurer et al., http://ccforum.com/content/16/5/R191

Published: 23 November 2012

Abstract

Volatile anesthetic agents have been used for decades in the peri-operative setting. Data from the past 15 years have shown that pre-injury administration of volatile anesthetic can decrease the impact of ischemia-reperfusion injury on the heart, brain, and kidney. Recent data demonstrated that volatile agents administered shortly after injury can decrease the ischemia-reperfusion injury. Several questions need to be answered to optimize this therapeutic target, but this is a promising era of secondary injury mitigation.