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Highly Accessed Commentary

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

Brendon P Scicluna1 and Tom van der Poll12*

Author Affiliations

1 Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105AZ Amsterdam, The Netherlands

2 Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105AZ Amsterdam, The Netherlands

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Critical Care 2012, 16:188  doi:10.1186/cc11893


See related research by Wong et al., http://ccforum.com/content/16/5/R213

Published: 27 December 2012

Abstract

Sepsis is a complex clinical condition that is driven predominantly by deviations from the orderly stereotypic immunological response to infection. Much effort has been undertaken in the search for biomarkers that can assist in discriminating critically ill patients with sterile inflammation from those with sepsis. Such biomarkers may aid the clinician in therapeutic decision making upon admission of a patient. Interleukin-27 may be such a discriminative biomarker, as suggested in the previous issue of Critical Care by a study of critically ill children.