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Highly Accessed Letter

Assessment of hemodynamic efficacy and safety of 6% hydroxyethyl starch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: how to guide fluid therapy?

Oliver Hunsicker and Roland C Francis*

Author Affiliations

Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany

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Critical Care 2012, 16:464  doi:10.1186/cc11836


See related research by Guidet et al., http://ccforum.com/content/16/3/R94

Published: 15 November 2012

First paragraph (this article has no abstract)

We argue that assessing the hemodynamic efficacy of hydroxyethyl starch (HES) versus NaCl in patients with severe sepsis requires an algorithm to direct the timing and amount of fluid resuscitation. Such an algorithm may include hemodynamic flow parameters.