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This article is part of the supplement: Sepsis 2012

Poster presentation

Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats

S Chien1*, Y Li2 and M Liu2

  • * Corresponding author: S Chien

Author Affiliations

1 Tainan University of Technology, Tainan, Taiwan

2 National Cheng Kung University, Tainan, Taiwan

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Critical Care 2012, 16(Suppl 3):P70  doi:10.1186/cc11757


The electronic version of this article is the complete one and can be found online at: http://ccforum.com/content/16/S3/P70


Published:14 November 2012

© 2012 Chien et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Polymicrobial infection is associated with systemic inflammatory response, which is involved in the pathogenesis and development of acute kidney injury (AKI) [1,2]. In this study, we examined the effect of sesamol against AKI in cecal-ligation-and-puncture (CLP)-treated rats.

Methods

Rats were given two subcutaneous doses of sesamol (10 mg/kg) 0 and 6 hours after CLP. Serum and kidney tissue were sampled 12 hours after CLP. Renal function and proinflammatory mediators, such as IL-1β, IL-6, and nitrite production were detected. Systemic oxidative stress was assessed by determining nitric oxide, superoxide anion, and xanthine oxidase activities. In addition, inducible nitric oxide synthase (iNOS) expression was also assessed in leukocytes from rats with AKI.

Results

The levels of serum BUN, CRE, IL-1β, IL-6, nitrite, iNOS expression, superoxide anion, and xanthine oxidase activity were significantly higher in rats after CLP. Sesamol significantly inhibited all parameters in CLP-treated rats.

Conclusion

Sesamol attenuated AKI by inhibiting neutrophil-initiated systemic inflammation and oxidative stress in CLP-treated rats.

Acknowledgements

This study was supported by grants from the National Science Council, Taiwan.

References

  1. Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, Hayes PC, Simpson KJ: The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure.

    Gut 2009, 58:443-449. PubMed Abstract | Publisher Full Text OpenURL

  2. Li YH, Hsu DZ, Liu MY: Sesamol attenuates systemic inflammation-associated acute kidney injury in polymicrobial infectious rats. In Science Against Microbial Pathogens: Communicating Current Research and Technological Advances. Edited by Mendez-Vilas A. Badajoz, Spain: Formatex Research Center; 2011:504-510. OpenURL