Rats were given two subcutaneous doses of sesamol (10 mg/kg) 0 and 6 hours after CLP. Serum and kidney tissue were sampled 12 hours after CLP. Renal function and proinflammatory mediators, such as IL-1β, IL-6, and nitrite production were detected. Systemic oxidative stress was assessed by determining nitric oxide, superoxide anion, and xanthine oxidase activities. In addition, inducible nitric oxide synthase (iNOS) expression was also assessed in leukocytes from rats with AKI.
The levels of serum BUN, CRE, IL-1β, IL-6, nitrite, iNOS expression, superoxide anion, and xanthine oxidase activity were significantly higher in rats after CLP. Sesamol significantly inhibited all parameters in CLP-treated rats.
Sesamol attenuated AKI by inhibiting neutrophil-initiated systemic inflammation and oxidative stress in CLP-treated rats.
This study was supported by grants from the National Science Council, Taiwan.
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