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Highly Accessed Commentary

A week seems to be weak: tailoring duration of antibiotic treatment in Gram-negative ventilator-associated pneumonia

Ignacio Martin-Loeches1 and Antoni Torres2*

Author Affiliations

1 Critical Care Centre, Corporación Sanitaria Universitaria Parc Tauli, Sabadell University Hospital, Universidad Autónoma de Barcelona, CIBER Enfermedades Respiratorias, Parc Taulí, 1 08208 Sabadell, Barcelona, Spain

2 Servei de Pneumologia, Institut Clinic del Tòrax, Hospital Clinic, Barcelona, IDIBAPS, CIBER Enfermedades Respiratorias, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain

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Critical Care 2012, 17:106  doi:10.1186/cc11899


See related research by Kollef et al., http://ccforum.com/content/16/6/R218

Published: 21 January 2013

Abstract

The optimal length of antimicrobial therapy has not been extensively studied for a great majority of infections and, in critically ill patients affected by ventilator-associated pneumonia, is a persisting and unsolved issue confronting clinicians. The integration of biomarkers, clinical judgment, and microbiologic eradication might help to define a shorter duration for some ventilator-associated pneumonia episodes due to non-fermenting Gram-negative bacilli, but until these strategies are implemented in clinical practice for individualizing antibiotic treatment, a short-course duration does not seem to tailor a long benefit.