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Highly Accessed Letter

Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients

Maik Sossdorf12, Gordon P Otto13, Janina Boettel2, Johannes Winning1 and Wolfgang Lösche12*

Author Affiliations

1 Clinic for Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany

2 Center for Sepsis Control and Care, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany

3 Department of Internal Medicine, Division of Nephrology, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany

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Critical Care 2012, 17:402  doi:10.1186/cc11886

Published: 8 January 2013

Abstract

Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality. However, the benefit was abolished when aspirin and NSAIDs were given together.