Lipid peroxidation in multidrug-resistant Gram-negative sepsis: translating science to the septic patient?
1 Department of Anesthesiology, Hospital of the Ludwigs-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany
2 pharmazentrum frankfurt/ZAFES, Hospital of the Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
3 Division of Emergencies and Critical Care, Department of Anaesthesiology, Oslo University Hospital, PO Box 4950, 0424 Oslo, Norway
Critical Care 2013, 17:120 doi:10.1186/cc12505
See related research by Toufekoula et al., http://ccforum.com/content/17/1/R6
Published: 1 March 2013Abstract
Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this dual experimental and clinical approach argue for highly compartmentalized lipid peroxidation during sepsis. Establishing a correlation between MDA concentration and survival provides valuable insights into the pathophysiology of Gram-negative sepsis. Yet, further studies are needed to understand and establish MDA as a biomarker during sepsis aggravated by organ failure.
