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Commentary

Lipid peroxidation in multidrug-resistant Gram-negative sepsis: translating science to the septic patient?

Patrick Scheiermann12* and Soeren E Pischke3

Author Affiliations

1 Department of Anesthesiology, Hospital of the Ludwigs-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany

2 pharmazentrum frankfurt/ZAFES, Hospital of the Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

3 Division of Emergencies and Critical Care, Department of Anaesthesiology, Oslo University Hospital, PO Box 4950, 0424 Oslo, Norway

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Critical Care 2013, 17:120  doi:10.1186/cc12505


See related research by Toufekoula et al., http://ccforum.com/content/17/1/R6

Published: 1 March 2013

Abstract

Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this dual experimental and clinical approach argue for highly compartmentalized lipid peroxidation during sepsis. Establishing a correlation between MDA concentration and survival provides valuable insights into the pathophysiology of Gram-negative sepsis. Yet, further studies are needed to understand and establish MDA as a biomarker during sepsis aggravated by organ failure.