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Highly Accessed Letter

Toothbrushing for preventing ventilator-associated pneumonia

Sonia O Labeau12 and Stijn I Blot1234*

Author Affiliations

1 Faculty of Education, Health and Social Work, University College Ghent, Ghent, Belgium

2 Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium

3 Department of General Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium

4 University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium

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Critical Care 2013, 17:417  doi:10.1186/cc12511


See related research by Gu et al., http://ccforum.com/content/16/5/R190


The electronic version of this article is the complete one and can be found online at: http://ccforum.com/content/17/2/417


Published:5 March 2013

© 2013 BioMed Central Ltd

Letter

Research on the potential contribution of oral care in preventing ventilator-associated pneumonia (VAP) has led to the generally accepted practice of using oral antiseptic agents [1]; however, the value of toothbrushing remains controversial.

Dr Gu and colleagues [2] investigated the effect of oral care with versus without toothbrushing on VAP prevention by meta-analysis, and found toothbrushing not to significantly reduce VAP incidence (risk ratio 0.77, 95% confidence interval 0.50 to 1.21). We feel, however, uncomfortable with the message that '... there is currently a lack of evidence to support toothbrushing in patients receiving mechanical ventilation'. This phrase might instigate healthcare professionals to abstain from brushing patients' teeth while the primary objective of toothbrushing is to maintain oral health, not to prevent VAP. A potential VAP risk reduction should rather be considered as a favorable side effect.

Also, two studies [3,4] in which VAP diagnosis was exclusively based on a Clinical Pulmonary Infection Score (CPIS) ≥6 were included in the meta-analysis. The CPIS is known to have moderate performance as well as considerable interobserver variability, and has been shown not to differentiate adequately between patients with VAP and systemic inflammatory response syndrome [5]. Our concern is well illustrated by Munro et al. [4] reporting to have unexpectedly found 115/192 patients with CPIS ≥6 at day 1 of data collection. This diagnostic issue may have yielded a vast overestimation of VAP rates and could have been acknowledged. We encourage researchers to use more stringent definitions for VAP diagnosis in future investigations.

Abbreviations

CPIS: clinical pulmonary infection score; VAP: ventilator-associated pneumonia.

Competing interests

SIB gives lectures on oral care for Kimberley-Clark. SOL gave a one-time presentation on oral care for Kimberley-Clark at the 2011 Annual Congress of the European Society for Intensive Care Medicine, Berlin. SOL held a doctorate research mandate from University College Ghent (2006-2012) and SIB holds a research mandate from the special research fund at Ghent University (Belgium).

References

  1. Labeau SO, Van de Vyver K, Brusselaers N, Vogelaers D, Blot SI: Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis.

    Lancet Infect Dis 2011, 11:845-854. PubMed Abstract | Publisher Full Text OpenURL

  2. Gu WJ, Gong YZ, Pan L, Ni YX, Liu JC: Impact of oral care with versus without toothbrushing on the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials.

    Crit Care 2012, 16:R190. PubMed Abstract | BioMed Central Full Text OpenURL

  3. Yao LY, Chang CK, Maa SH, Wang C, Chen CC: Brushing teeth with purified water to reduce ventilator-associated pneumonia.

    J Nurs Res 2011, 19:289-297. PubMed Abstract | Publisher Full Text OpenURL

  4. Munro CL, Grap MJ, Jones DJ, McClish DK, Sessler CN: Chlorhexidine, toothbrushing, and preventing ventilator-associated pneumonia in critically ill adults.

    Am J Crit Care 2009, 18:428-437. PubMed Abstract | Publisher Full Text OpenURL

  5. Rea-Neto A, Youssef NC, Tuche F, Brunkhorst F, Ranieri VM, Reinhart K, Sakr Y: Diagnosis of ventilator-associated pneumonia: a systematic review of the literature.

    Crit Care 2008, 12:R56. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL