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Highly Accessed Letter

Tissue hypoxia during acute hemorrhage

Philippe Haouzi

Author Affiliations

Division of Pulmonary and Critical Care Medicine, Penn State University College of Medicine, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA

Critical Care 2013, 17:423  doi:10.1186/cc12519


See related commentary by Calzia et al., http://ccforum.com/content/16/6/183

Published: 28 March 2013

First paragraph (this article has no abstract)

Calzia and colleagues argue [1] that tissue hypoxia in a rat model of hemorrhage that led to an oxygen deficit of 120 ml/kg with hyperlactacidemia [2] may be modest, and may not affect hydrogen sulfide oxidation since '... the arterial oxygen partial pressure was still normal ...' [1]. This contention requires clarification.