Email updates

Keep up to date with the latest news and content from Critical Care and BioMed Central.

Highly Accessed Letter

Target blood pressure in sepsis: between a rock and a hard place

Thiago Domingos Corrêa, Jukka Takala and Stephan Mathias Jakob*

Author Affiliations

Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10. CH-3010, Bern, Switzerland

For all author emails, please log on.

Critical Care 2013, 17:433  doi:10.1186/cc12692


See related commentary by Beloncle et al., http://ccforum.com/content/17/2/126 and related research by Corrêa et al., http://ccforum.com/content/17/1/R21

Published: 17 May 2013

First paragraph (this article has no abstract)

We acknowledge the constructive comments of Beloncle and colleagues [1] regarding our recently published study. We demonstrated that targeting a mean arterial blood pressure (MAP) between 50 and 60 mmHg (Low-MAP) in porcine fecal peritonitis was associated with increased incidence of acute kidney injury (AKI) in comparison to targeting a MAP between 75 and 85 mmHg (High-MAP), which resulted in increased net positive fluid balance and vasopressor load [2].