The gut-brain axis in the critically ill: Is glucagon-like peptide-1 protective in neurocritical care?
1 Discipline of Acute Care Medicine, Level 5, Eleanor Harold Building, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000
2 Intensive Care Unit, Level 4, Emergency Services Building, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia 5000
3 Diabetes Division, Department of Medicine I, St Josef Hospital, Klinikum der Ruhr Universität Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Critical Care 2013, 17:163 doi:10.1186/cc12758
See related research by Bakiner et al., http://ccforum.com/content/17/3/R123Published: 9 July 2013
Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.