|
Critical appraisal of animal model studies |
| Study selection |
| Indication (eg sepsis) |
| Category |
| Pathophysiology |
| Therapy |
| Other |
| Study assessment |
| Validity of results |
| Randomization |
| Accounting for all experimental subjects |
| Blinding |
| Comparability of groups at baseline |
| Lack of confounders |
| Specific findings |
| Effect size |
| Precision |
| Generalizability to corresponding clinical indication |
| Clinical relevance of animal model |
| Supportive therapies similar to those in the clinical setting |
| Consideration of intercurrent illness |
| Species specificity of the model |
| Potential cost-effectiveness |
| Evidence-based recommendations |
| Strength of evidence |
| Quality of evidence |
Sibbald Critical Care 2000 4(Suppl 2):S8 doi:10.1186/cc970 |