|
Specific approaches to treatment of toxic shock syndromes |
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| Strategy |
Experimental data |
Reference |
|
|
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| Clindamycin |
Toxin production is switched off at sub-bacteriocidal concentrations of antibiotic. |
[5,6] |
| Clindamycin use is associated with reduced mortality compared with historical controls |
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| Intravenous immunoglobulin |
Immunoglobulin neutralizes streptococcal pyrogenic exotoxins in vitro. IgA and IgM |
[7,8,9] |
| supplemented preparations may be superior to pure IgG preparations. Adjunctive therapy |
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| with intravenous immunoglobulin is associated with improved survival compared with |
||
| historical controls |
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| Toxoids of pyrogenic exotoxins |
Non-superantigenic mutants of SPEA and SPEC protect rabbits from a toxin challenge |
[10,11] |
|
SPEA, Streptococcal pyrogenic exotoxin A; SPEC, streptococcal pyrogenic exotoxin C. | ||
Llewelyn and Cohen Critical Care 2001 5:53 doi:10.1186/cc986 |
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