|
Summary of the major studies on the use of steroids in the treatment of sepsis |
||
| Author |
Treatment protocol |
Outcome |
|
|
||
| Klastersky J et al 1971 [1] |
Betamethasone 1 mg/kg for 3 days |
No difference in mortality |
| Schumer et al 1976 [2] |
2 part study: |
|
| Part 1 (prospective study): dexamethasone 3 mg/kg or |
||
| methylprednisolone 30 mg/kg or placebo |
Decrease in mortality |
|
| Part 2 (retrospective study) dexamethasone or |
||
| methylprednisolone or placebo |
Decrease in mortality |
|
| Lucas and Ledgerwood 1984 [3] |
Dexamethasone 6 mg/kg for 48 h |
No difference in mortality |
| Sprung et al 1984 [4] |
Methylprednisolone 30 mg/kg, dexamethasone 6 mg/kg |
Decrease in mortality |
| Bone et al 1987 [5] |
Multicentre study |
|
| Methylprednisolone 30 mg/kg 4 doses over 24 h |
Increase in mortality |
|
| Hinshaw et al 1987 [6] |
Methylprednisolone 30 mg/kg |
No difference in mortality |
| Luce et al 1988 [7] |
Methylprednisolone 30 mg/kg 4 doses over 24 h |
No difference in mortality |
Smith Critical Care 2001 5:72 doi:10.1186/cc990 |
||