Table 2

Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and to dobutamine plus INO in all patients. The baseline values presented are the means of the three baseline studies assessed before each challenge

Baseline
 INO
 Dobutamine
 INO+Dobutamine
Cardiac index (l/min/m2)
 3.2 ± 1.2
 3.2 ± 1.2
 4.7 ± 1.2**
 4.4 ± 1.2**
Heart rate (beats/min)
 87 ± 18
 86 ± 17
 113 ± 18**
 109 ± 19**
SVI (ml/m2)
 36 ± 10
 37 ± 9
 44 ± 16**
 41 ± 11**
CVP (mmHg)
 2.5 ± 2.8
 3.1 ± 3.1
 2.4 ± 2.5
 2.7 ± 2.9
MPAP (mmHg)
 26 ± 10
 24 ± 9**
 31 ± 15*
 27 ± 12
PAOP (mmHg)
 7 ± 3
 7.4 ± 4
 8 ± 4
 7 ± 3
MPAP-PAOP (mmHg)
 19 ± 10
 17 ± 9**
 23 ± 14
 20 ± 11
PVRI (dyne/s/cm5/m2)
 535 ± 285
 477 ± 293*
 441 ± 331
 416 ± 265**
MAP (mmHg)
 86 ± 11
 87 ± 10
 86 ± 10
 85 ± 10
SVRI (dyne/s/cm5/m2)
 2363 ± 764
 2348 ± 786
 1346 ± 243**
 1614 ± 439**
Qs/Qt (%)
 23 ± 5
 20 ± 5*
 26 ± 5**
 25 ± 7
PaO2/FiO2 (mmHg)
 327 ± 90
 418 ± 104**
 296 ± 90*
 390 ± 111**
PaCO2 (mmHg)
 51 ± 12
 52 ± 12
 51 ± 13
 50 ± 13

*P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index.

Vizza et al. Critical Care 2001 5:355   doi:10.1186/cc1069