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Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in bronchiectasis (9 patients) |
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| Baseline 1 |
INO |
Dobutamine |
INO+Dobutamine |
|
|
|
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| Cardiac index (l/min/m2) |
3.9 ± 1.9 |
3.8 ± 1.5 |
5.6 ± 1.4 |
4.5 ± 0.3 |
| Heart rate (beats/min) |
87 ± 17 |
85 ± 12 |
115 ± 25 |
114 ± 23* |
| SVI (ml/m2) |
43 ± 15 |
43 ± 13 |
53 ± 27 |
42 ± 12 |
| CVP (mmHg) |
3.2 ± 2.8 |
4 ± 3 |
3.2 ± 2.7 |
3.2 ± 3.9 |
| MPAP (mmHg) |
33 ± 16 |
28 ± 14 |
37 ± 17 |
36 ± 17 |
| PAOP (mmHg) |
9.4 ± 2 |
7.8 ± 1 |
12.5 ± 5 |
9.2 ± 3.3 |
| MPAP-PAOP (mmHg) |
24 ± 15 |
20 ± 14 |
24 ± 17 |
27 ± 18 |
| PVRI (dyne/s/cm5/m2) |
781 ± 424 |
662 ± 355 |
569 ± 321 |
641 ± 335* |
| MAP (mmHg) |
86 ± 10 |
88 ± 9 |
90 ± 14 |
79 ± 11 |
| SVRI (dyne/s/cm5/m2) |
1919 ± 684 |
1974 ± 712 |
1272 ± 256 |
1391 ± 237* |
| Qs/Qt (%) |
19 ± 5 |
11 ± 4* |
24 ± 7 |
15 ± 12 |
| PaO2/FiO2 (mmHg) |
366 ± 113 |
448 ± 92 |
344 ± 95 |
435 ± 115 |
| PaCO2 (mmHg) |
51 ± 20 |
52 ± 23 |
53 ± 24 |
56 ± 23 |
|
*P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index. | ||||
Vizza et al. Critical Care 2001 5:355 doi:10.1186/cc1069 |
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