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Hemodynamic and gas exchange response to inhaled nitric oxide (INO), dobutamine, and INO plus dobutamine in severe chronic obstructive pulmonary disease (COPD) (11 patients) |
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| Baseline |
INO |
Dobutamine |
INO+Dobutamine |
|
|
|
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| Cardiac index (l/min/m2) |
3.2 ± 1.9 |
3.2 ± 2.3 |
5.0 ± 2.7 |
4.7 ± 2.4** |
| Heart rate (beats/min) |
83 ± 28 |
83 ± 30 |
104 ± 28 |
101 ± 29* |
| SVI (ml/m2) |
38 ± 11 |
39 ± 13 |
49 ± 18 |
47 ± 19 |
| CVP (mmHg) |
2.5 ± 3 |
2.5 ± 3.1 |
2.0 ± 1.8 |
2.0 ± 2.0 |
| MPAP (mmHg) |
23 ± 7 |
21 ± 7 |
25 ± 8 |
24 ± 9 |
| PAOP (mmHg) |
6.6 ± 4.5 |
6.0 ± 4.9 |
5.3 ± 4.7 |
5.0 ± 4.0 |
| MPAP-PAOP (mmHg) |
16 ± 8 |
15 ± 6 |
19 ± 7* |
19 ± 9 |
| PVRI (dyne/s/cm5/m2) |
671 ± 277 |
601 ± 247 |
471 ± 262* |
492 ± 300* |
| MAP (mmHg) |
87 ± 12 |
89 ± 11 |
91 ± 9 |
93 ± 12 |
| SVRI (dyne/s/cm5/m2) |
2524 ± 873 |
2625 ± 1012 |
1654 ± 541 |
1824 ± 683** |
| Qs/Qt (%) |
23 ± 11 |
15 ± 6 |
28 ± 10* |
17 ± 5 |
| PaO2/FiO2 (mmHg) |
322 ± 115 |
442 ± 103* |
310 ± 93 |
419 ± 90* |
| PaCO2 (mmHg) |
45 ± 11 |
44 ± 11 |
43 ± 11 |
45 ± 13 |
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*P < 0.05; **P < 0.01. CVP, cardiovenous pressure; INO, inhaled nitric oxide; MAP, mean systemic arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary artery occluded pressure; PVRI, pulmonary vascular resistance index; SVI, systemic vascular index; SVRI, systemic vascular resistance index. | ||||
Vizza et al. Critical Care 2001 5:355 doi:10.1186/cc1069 |
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