References

  1. Esmon C: Cell mediated events that control blood coagulation and vascular injury.

    Ann Rev Cell Devel Biol 1993, 9:1-26. Publisher Full Text OpenURL

  2. Waugh JM, Li-Hawkins J, Yuksel E, Kuo MD, Cifra PN, Hilfiker PR, Geske R, Chawla M, Thomas J, Shenaq SM, Dake MD, Woo SLC: Thrombomodulin overexpression to limit neointima formation.

    Circulation 2000, 102:332-337. PubMed Abstract | Publisher Full Text OpenURL

  3. Esmon CT: Natural anticoagulants and their pathways.

    In: Antithrombotics (Handbook of Experiemental Pharmacology, vol 132. Edited by Uprichard ACG, Gallagher KP. Heidelberg: Springer-Verlag; 1999, 447-476. OpenURL

  4. Fukudome K, Esmon CT: Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor.

    J Biol Chem 1994, 269:26486-26491. PubMed Abstract | Publisher Full Text OpenURL

  5. Esmon CT: The endothelial cell protein C receptor.

    Thromb Haemost 2000, 83:639-643. PubMed Abstract OpenURL

  6. Busch C, Cancilla P, DeBault L, Goldsmith J, Owen W: Use of endothelium cultured on microcarriers as a model for the microcirculation.

    Lab Invest 1982, 47:498-504. PubMed Abstract OpenURL

  7. Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W: Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.

    Nature 2000, 404:518-525. PubMed Abstract | Publisher Full Text OpenURL

  8. Smith OP, White B: Infectious purpura fulminans: diagnosis and treatment.

    Br J Haematol 1999, 104:202-207. PubMed Abstract | Publisher Full Text OpenURL

  9. Esmon CT: Inflammation and thrombosis: mutual regulation by protein C.

    The Immunologist 1998, 6:84-89. OpenURL

  10. Esmon CT, Fukudome K, Mather T, Bode W, Esmon NL, Regan LM, Stearns-Kurosawa DJ, Kurosawa S: Inflammation: the protein C pathway.

    Fibrinolysis Proteolysis 1997, 11:143-148. OpenURL

  11. Taylor FB Jr, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE: Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

    J Clin Invest 1987, 79:918-925. PubMed Abstract | PubMed Central Full Text OpenURL

  12. Taylor F, Chang A, Ferrell G, Mather T, Catlett R, Blick K, Esmon CT: C4b-binding protein exacerbates the host response to Escherichia coli.

    Blood 1991, 78:357-363. PubMed Abstract | Publisher Full Text OpenURL

  13. Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ: Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.

    Proc Natl Acad Sci USA 1985, 82:1121-1125. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  14. Bajzar L, Morser J, Nesheim M: TAFI or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex.

    J Biol Chem 1996, 271:16603-16608. PubMed Abstract | Publisher Full Text OpenURL

  15. Bajzar L, Manuel R, Nesheim ME: Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor.

    J Biol Chem 1995, 270:14477-14484. PubMed Abstract | Publisher Full Text OpenURL

  16. Taoka Y, Okajima K, Uchiba M, Murakami K, Harada N, Johno M, Naruo M: Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes.

    J Neurosci 1998, 18:1393-1398. PubMed Abstract | Publisher Full Text OpenURL

  17. Mizutani A, Okajima K, Uchiba M, Noguchi T: Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation.

    Blood 2000, 95:3781-3787. PubMed Abstract | Publisher Full Text OpenURL

  18. Esmon CT:

    Activated Protein C. London: ReMedica Publishing; 2001, in press. OpenURL

  19. Kurosawa S, Esmon CT, Stearns-Kurosawa DJ: The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18.

    J Immunol 2000, 165:4697-4703. PubMed Abstract | Publisher Full Text OpenURL

  20. White B, Schmidt M, Murphy C, Livingstone W, O'Toole D, Lawler M, O'Neill L, Kelleher D, Schwarz HP, Smith OP: Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor κB (NF-κB) and tumour necrosis factor α (TNF-α) production in the THP-1 monocytic cell line.

    Br J Haematol 2000, 110:130-134. PubMed Abstract | Publisher Full Text OpenURL

  21. Hancock WW, Grey ST, Hau L, Akalin E, Orthner C, Sayegh MH, Salem HH: Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses.

    Transplantation 1995, 60:1525-1532. PubMed Abstract OpenURL

  22. Shu F, Kobayashi H, Fukudome K, Tsuneyoshi N, Kimoto M, Terao T: Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner.

    FEBS Lett 2000, 477:208-212. PubMed Abstract | Publisher Full Text OpenURL

  23. Taylor FB Jr, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang ACK, Laszik Z, Kosanke S, Peer G, Esmon CT: The endothelial cell protein C receptor aids in host defence against Escherichia coli sepsis.

    Blood 2000, 95:1680-1686. PubMed Abstract | Publisher Full Text OpenURL