Table 2

King's College Hospital criteria for liver transplantation in acetaminophen-induced acute liver failure

Current criteria [11]

Modified criteria [14]

List for transplantation if:

Strongly consider listing for transplantation if:

Arterial pH <7.3 after adequate fluid resuscitation

Arterial blood lactate concentration >3.5 mmol/l after early fluid resuscitation

List for transplantation if all three of the following occur within a 24-h period:

List for transplantation if:

• Creatinine >300 μmol/l

Arterial pH <7.3, or arterial blood lactate concentration >3.0 mmol/l after adequate fluid resuscitation

• PT >100 s (INR >6.5)

• Grade III/IV encephalopathy

List for transplantation if all three of the following occur within a 24-h period:

• Creatinine >300 μmol/l

• PT >100 s (INR >6.5)

• Grade III/IV encephalopathy

INR = International Normalized Ratio; PT = prothrombin time.

Dargan and Jones Critical Care 2002 6:108   doi:10.1186/cc1465