|
Selective decontamination of the digestive tract (SDD) schemes and outcomes of prospective randomized trials |
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| Reference |
Number of patients |
Pulmonary infection incidence (%), control versus SDD |
P value |
Mortality (%), control versus SDD |
P value |
|
|
|||||
| Aerdts et al. [14] |
88 |
69.2 vs 5.9 |
0.0001 |
15.4 vs 11.8 |
Not significant |
| Blair et al. [15] |
256 |
34.4 vs 9.7 |
0.002 |
21.4 vs 10.5 |
Not significant |
| de Jonge et al. [11] |
934 |
-a |
-a |
22.9 vs 14.8 |
0.002 |
| Cockerill et al. [16] |
150 |
18.6 vs 5.3 |
0.03 |
21.3 vs 14.7 |
Not significant |
| Jacobs et al. [17] |
79 |
9.3 vs 0 |
< 0.05 |
53.5 vs 38.8 |
Not significant |
| Kerver et al. [18] |
96 |
85.1 vs 12.2 |
< 0.01 |
32.0 vs 28.5 |
Not significant |
| Krueger et al. [19] |
546 |
11.1 vs 2.3 |
0.007 |
28.6 vs 19.6 |
Not significantb |
| Palomar et al. [20] |
83 |
50.0 vs 17.1 |
0.005 |
31.0 vs 24.4 |
Not significant |
| Rocha et al. [21] |
101 |
46.3 vs 14.9 |
< 0.001 |
44.4 vs 21.3 |
< 0.05c |
| Sanchez-Garcia et al. [22] |
271 |
29.3 vs11.5 |
0.05 |
47.1 vs 38.9 |
Not significant |
| Ulrich et al. [23] |
100 |
55.8 vs 14.6 |
< 0.001 |
53.8 vs 31.3 |
< 0.02c |
| Verwaest et al. [24] |
440 |
11.4 vs 6.6 |
< 0.05 |
16.8 vs 15.5 |
Not significant |
| Verwaest et al. [24] |
440 |
11.4 vs 7.0 |
< 0.05 |
17.6 vs 15.5 |
Not significant |
| Winter et al. [25] |
183 |
34.8 vs 3.3 |
< 0.01 |
43.5 vs 36.3 |
Not significant |
|
a Not evaluated. b Overall intensive care unit mortality was not statistically different, but the mortality was significantly reduced for patients with Acute Physiology and Chronic Health Evaluation II scores of 20–29 on admission. c Not significant on intention-to-treat analysis. | |||||
Schultz et al. Critical Care 2003 7:107 doi:10.1186/cc1873 |
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