Critical Care
Volume 7
Issue 2 |
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 CommentaryRed man syndromeSoupramanien Sivagnanam1  and Dirk Deleu2 1Senior Registrar, Department of Anaesthesia & Intensive Care, Sultan Qaboos University Hospital, Al Khod, Muscat, Oman 2Associate Professor, Department of Clinical Pharmacology, College of Medicine, Sultan Qaboos University, Al Khod, Muscat, Oman  author email corresponding author email
Critical Care 2003,
7:119-120doi:10.1186/cc1871
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23 December 2002 |
Abstract
Vancomycin can cause two types of hypersensitivity reactions, the red man syndrome and anaphylaxis. Red man syndrome has often been associated with rapid infusion of the first dose of the drug and was initially attributed to impurities found in vancomycin preparations. Even after improvement in vancomycin's purity, however, reports of the syndrome persist. Other antibiotics (e.g. ciprofloxacin, amphotericinB, rifampicin and teicoplanin) or other drugs that stimulate histamine release can result in red man syndrome. Discontinuation of the vancomycin infusion and administration of diphenhydramine can abort most of the reactions. Slow intravenous administration of vancomycin should minimize the risk of infusion-related adverse effects. | 
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