Table 8 |
|||
|
Classification by platelet counts of intracranial hemorrhages during infusion period and cross-classification with presence of meningitis in all clinical trials |
|||
|
ICH during infusion period |
|||
|
|
|||
|
Platelets (×103/mm3)1 |
Events2 |
Cumulative % of patients |
Meningitis |
|
|
|||
|
≤ 20 |
3/5 |
20.0% (3/15) |
1/3 |
|
>20 to ≤ 30 |
3/6 |
40.0% (6/15) |
1/3 |
|
>30 to ≤ 50 |
2/11 |
53.3% (8/15) |
0/2 |
|
>50 to ≤ 100 |
3/12 |
73.3% (11/15) |
2/3 |
|
>100 |
4/19 |
100.0% (15/15) |
2/4 |
|
Not available |
1/26 |
||
|
Total |
16/79 |
6/16 |
|
|
|
|||
|
A total of 2786 patients treated with drotrecogin alfa (activated) infusion were included in this analysis. 1Platelet counts were recorded within the preceding 24 hours of an intracerebral hemorrhage (ICH). 2Patients with an ICH/all patients with a serious bleeding event. |
|||
|
Bernard et al. Critical Care 2003 7:155 doi:10.1186/cc2167 |
|||
