Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

doi:10.1186/cc2392

Critical Care
Volume 7
Issue 6

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Broccard AF

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Review

Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

John J Marini¹ , John R Hotchkiss² and Alain F Broccard³

¹Professor, University of Minnesota, Regions Hospital, St Paul, Minnesota, USA

²Assistant Professor, University of Minnesota, Regions Hospital, St Paul, Minnesota, USA

³Associate Professor, University of Minnesota, Regions Hospital, St Paul, Minnesota, USA

author email corresponding author email

Critical Care 2003, 7:435-444doi:10.1186/cc2392


Published:	17 October 2003

Abstract

Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas–blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.