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Table 1
Contraindications and warnings for the use of drotrecogin alfa (activated)
Contraindications	Warnings

Active internal bleeding	Heparin >15 U/kg per hour
Recent (within 3 months) hemorrhagic stroke	International Normalized Ratio > 3
Recent (within 2 months) intracranial or intraspinal surgery or severe head trauma requiring hospitalization	Platelet count < 30,000/mm³, even if platelet count is increased after transfusions (USA) (European Agency for the Evaluation of Medicinal Products: contraindication)
Trauma with increased risk for life-threatening bleeding (e.g. liver, spleen or complicated pelvic fractures)	Recent gastrointestinal bleeding (within 6 weeks)
Patients with epidural catheters	Recent administration of thrombolytic therapy (within 3 days)
Patients with intracranial neoplasm or mass lesion, or evidence of cerebral herniation	Recent administration (< 7 days) of oral anticoagulant or glycoprotein IIb/IIIa inhibitors
	Recent administration (< 7 days) of aspirin > 650 mg/day or other platelet inhibitors
	Recent ischemic stroke (< 3 months)
	Intracranial arteriovenous malformation
	Known bleeding diathesis
	Chronic severe hepatic disease (e.g. Child–Pugh C)
	Any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location

Adapted from US Food and Drug Administration [2,3].
Laterre and Wittebole Critical Care 2003 7:445 doi:10.1186/cc2342

Table 1