|
Drotrecogin alfa (activated) infusion interruptions during procedures: recommended actions |
|
| Procedure |
Action |
|
|
|
| Minor procedures |
|
| Arterial line insertion (radial or femoral) |
Hold infusion for 2 hours before procedure and restart immediately after, in the absence of bleeding |
| Venous femoral line insertion |
|
| Intubation or tracheostomy change (unless urgent) |
|
| More invasive procedures |
|
| Central line or Swan-Ganz insertion (subclavian or jugular) |
Hold infusion for 2 hours before and restart 2 hours after, in the absence of bleeding |
| Lumbar puncture |
|
| Chest tube insertion or thoracocentesis |
|
| Paracentesis |
|
| Percutaneous drainage |
|
| Nephrostomy |
|
| Gastroscopy (possible biopsy) |
|
| Wound debridment (decubitus ulcer, infected wound, packing changes in open abdomen, etc.) |
|
| Major procedures |
|
| Surgery (laparotomy, thoracotomy, major debridment, etc.) |
Hold infusion for 2 hours and wait for 12 hours before restarting infusion |
| Epidural catheter |
For epidural catheter, do not use drotrecogin or wait for 12 hours after removal before starting drug infusion |
|
Adapted from Taylor and coworkers [19]. | |
Laterre and Wittebole Critical Care 2003 7:445 doi:10.1186/cc2342 |
|