Research

The effects of different weaning modes on the endocrine stress response

Guniz Meyanci Koksal¹ , Cem Sayilgan¹, Oznur Sen² and Huseyin Oz³

¹Senior Resident, Department of Anaesthesiology and Reanimation, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

²Resident, Department of Anaesthesiology and Reanimation, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

³Professor, Department of Anaesthesiology and Reanimation, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

author email corresponding author email

Critical Care 2004, 8:R31-R34doi:10.1186/cc2413

Published:	3 December 2003

Abstract

Introduction

The aim of the present study was to investigate the effects of the stress response on plasma insulin, cortisol, glucose, and urinary vanilmandelic acid during weaning and after extubation, using pressure support (PS), continuous positive airway pressure (CPAP) and T-piece modes.

Methods

Sixty patients were randomly divided into three groups (n = 20). The PS group received FiO₂ ≤ 0.4, PS ≤ 10 cmH₂O, and positive end expiratory pressure ≤ 5 cmH₂O for 2 hours. The CPAP group was given FiO₂ ≤ 0.4 and CPAP 5 ≤ cmH₂O for 2 hours. The T-piece group (group T) received 4 l/min oxygen via a T-piece for 2 hours. After 1 hour and 2 hours in their respective weaning modes, blood and urine samples were taken for insulin, cortisol, glucose and vanilmandelic acid measurements. Forty-eight hours after extubation, blood and urine samples were again taken.

Results

Plasma insulin was greater in group T than in the PS and CPAP groups (P < 0.01 and P < 0.01). The plasma cortisol concentration was greater in group T than in group PS during weaning (P < 0.05) and after extubation (P < 0.05). Blood glucose concentrations were greater in group T than in the other groups (both P < 0.01) both during weaning and post extubation. Urine vanilmandelic acid was greater in group T than in the other groups during weaning and after extubation (both P < 0.001).

Conclusion

Weaning via the T-piece caused a greater stress response than the PS and CPAP modes.