Critical Care

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Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]

Gary T Kinasewitz, S Betty Yan*, Bruce Basson, Philip Comp, James A Russell, Alain Cariou, Suzane L Um, Barbara Utterback, Pierre-Francois Laterre, Jean-François Dhainaut and for the PROWESS Sepsis Study Group

Critical Care 2004, 8:R82-R90 doi:


See related Commentary: http://ccforum.com/content/8/2/99

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Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)

Andrew F Shorr, Jonathan M Janes, Antonio Artigas, Jyrki Tenhunen, Duncan LA Wyncoll, Emmanuelle Mercier, Bruno Francois, Jean-Louis Vincent, Burkhard Vangerow, Darell Heiselman, Amy G Leishman, Yajun E Zhu, Konrad Reinhart, Critical Care 2010, 14:R229 (21 December 2010)

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Sepsis biomarkers: a review

Charalampos Pierrakos, Jean-Louis Vincent Critical Care 2010, 14:R15 (9 February 2010)

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Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis

Leonardo Lorente, María M Martín, Lorenzo Labarta, César Díaz, Jordi Solé-Violán, José Blanquer, Josune Orbe, José A Rodríguez, Alejandro Jiménez, Juan M Borreguero-León, Felipe Belmonte, Juan C Medina, Maria C LLimiñana, José M Ferrer-Agüero, José Ferreres, María L Mora, Santiago Lubillo, Manuel Sánchez, Ysamar Barrios, Antonio Sierra, José A Páramo Critical Care 2009, 13:R158 (2 October 2009)

Original clinical investigation   Open Access

Plasma fibrinolysis is related to the degree of organ dysfunction but not to the concentration of von Willebrand Factor in critically ill patients

Karim Boudjeltia, Sandra Ollieuz, Michael Piagnerelli, Patrick Biston, Philippe Cauchie, Jean-Louis Vincent, Dany Brohee, Michel Vanhaeverbeek Thrombosis Journal 2009, 7:10 (19 June 2009)

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Collagen-related biomarkers in severe sepsis: a big stretch?

Gavin Morrison, Douglas D Fraser Critical Care 2009, 13:154 (2 June 2009)

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Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study

Fritz Daudel, Ulf Kessler, Hélène Folly, Jasmin S Lienert, Jukka Takala, Stephan M Jakob Critical Care 2009, 13:R42 (30 March 2009)

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Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)

Andrew F Shorr, David R Nelson, Duncan LA Wyncoll, Konrad Reinhart, Frank Brunkhorst, George Vail, Jonathan Janes Critical Care 2008, 12:R45 (4 April 2008)

Protein C was the only variable consistently correlated with both DrotAA treatment effect and survival based on systematic analyses of 6 biomarkers and 5 organ dysfunctions measured in severe sepsis clinical trials.

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The protein C pathway: implications for the design of the RESPOND study

Burkhard Vangerow, Andrew F Shorr, Duncan Wyncoll, Jonathan Janes, David R Nelson, Konrad Reinhart Critical Care 2007, 11(Suppl 5):S4 (19 December 2007)

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Antithrombin supplementation for anticoagulation during continuous hemofiltration in critically ill patients with septic shock: a case-control study

Damien du Cheyron, Bruno Bouchet, Cédric Bruel, Cédric Daubin, Michel Ramakers, Pierre Charbonneau Critical Care 2006, 10:R45 (13 March 2006)

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New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)

William L Macias, S Betty Yan, Mark D Williams, Suzane L Um, George E Sandusky, Darryl W Ballard, Jean-Michel S Planquois Critical Care 2005, 9(Suppl 4):S38-S45 (25 August 2005)

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Year in review in Critical Care, 2004: sepsis and multi-organ failure

James M O'Brien, Naeem A Ali, Edward Abraham Critical Care 2005, 9:409-413 (23 May 2005)

Research   Open Access

The role of d-dimer as first marker of thrombophilia in women affected by sterility: implications in pathophysiology and diagnosis of thrombophilia induced sterility

Pierpaolo Di Micco, Maristella D'Uva, Ida Strina, Antonio Mollo, Valeria Amato, Alferio Niglio, Giuseppe De Placido Journal of Translational Medicine 2004, 2:38 (9 November 2004)

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Coagulation in sepsis: all bugs bite equally

Marcel Levi, Tom van der Poll Critical Care 2004, 8:99-100 (10 February 2004)