Figure 1.

The time courses of biomarkers of coagulation in placebo-treated patients with severe sepsis in the PROWESS study are shown here as means and 95% confidence intervals, using standard error of the mean and repeated measures analysis without imputing for missing data. The number of observations for each time point appears below the x-axis for (●) survivors and (○) nonsurvivors. *P < 0.05 versus nonsurvivors. APTT, activated partial thromboplastin time; PT, prothrombin time.